Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2213987..2214504 Replicon chromosome
Accession NZ_CP068159
Organism Corynebacterium riegelii strain FDAARGOS_1114

Toxin (Protein)


Gene name yoeB Uniprot ID A0A2I1V4I0
Locus tag I6I71_RS10555 Protein ID WP_070495846.1
Coordinates 2213987..2214241 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A0K1R9V6
Locus tag I6I71_RS10560 Protein ID WP_052203851.1
Coordinates 2214241..2214504 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I71_RS10530 2209906..2210604 + 699 WP_201820902.1 peroxide stress protein YaaA -
I6I71_RS10535 2210684..2211805 + 1122 WP_070495853.1 ATP-binding protein -
I6I71_RS10540 2211835..2212557 + 723 WP_201820904.1 DUF1648 domain-containing protein -
I6I71_RS10545 2212554..2213237 + 684 WP_201820906.1 thermonuclease family protein -
I6I71_RS10550 2213241..2213990 + 750 WP_101734421.1 NAD-dependent deacylase -
I6I71_RS10555 2213987..2214241 - 255 WP_070495846.1 Txe/YoeB family addiction module toxin Toxin
I6I71_RS10560 2214241..2214504 - 264 WP_052203851.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
I6I71_RS10565 2214545..2215504 - 960 WP_201820909.1 methyltransferase -
I6I71_RS10570 2215488..2216228 - 741 WP_052203847.1 uroporphyrinogen-III C-methyltransferase -
I6I71_RS10575 2216253..2217446 + 1194 WP_201820911.1 YdiU family protein -
I6I71_RS10580 2217471..2218982 - 1512 WP_201820913.1 malate dehydrogenase (quinone) -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2133700..2263042 129342


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-66)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10110.62 Da        Isoelectric Point: 9.3942

>T186802 WP_070495846.1 NZ_CP068159:c2214241-2213987 [Corynebacterium riegelii]
MRLVWTSHAWEDYLHWQANDKKMLKRVNQLLRDTLRDPFEGIGKPEPLKYGAEGAWSRRITQEHRLVYMIVDGDLVVLQA
RYHY

Download         Length: 255 bp

>T186802 NZ_CP089772:c3110725-3110369 [Mycobacterium tuberculosis]
GTGATGCGCCGCGGTGAGATTTGGCAGGTCGATCTCGACCCCGCTCGAGGTAGCGAAGCGAACAACCAGCGCCCCGCCGT
CGTCGTCAGCAACGACCGGGCCAACGCGACCGCCACGCGTCTTGGGCGCGGCGTCATCACCGTCGTGCCGGTGACGAGCA
ACATCGCCAAGGTCTATCCGTTTCAGGTGTTGTTGTCGGCCACCACTACTGGTCTCCAGGTCGACTGCAAGGCGCAGGCC
GAGCAAATCAGATCGATTGCTACCGAGCGGTTGCTCCGGCCAATCGGCCGAGTTTCAGCCGCCGAACTTGCCCAGCTCGA
TGAGGCTTTGAAACTGCATCTCGACTTATGGTCGTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9826.82 Da        Isoelectric Point: 4.1839

>AT186802 WP_052203851.1 NZ_CP068159:c2214504-2214241 [Corynebacterium riegelii]
MSISASEARRTLYPLIQQVNNDRDAVEIVSRHGNAVLMSAEDYEAWLETAYLFKTRENARRLTQAYEDALNGAVAEHDVD
LDVELDA

Download         Length: 264 bp

>AT186802 NZ_CP089772:c3110939-3110709 [Mycobacterium tuberculosis]
GTGAAGTTGAGCGTGAGCCTGTCCGATGACGACGTCGCGATCCTGGACGCATATGTGAAACGAGCGGGATTACCATCCCG
CTCCGCCGGCCTGCAGCATGCGATCCGCGTGCTTCGCTACCCCACGCTCGAAGATGACTATGCCAACGCATGGCAAGAAT
GGTCGGCAGCCGGCGACACGGACGCGTGGGAGCAGACCGTCGGCGACGGAGTCGGTGATGCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I1V4I0

Antitoxin

Source ID Structure
AlphaFold DB A0A0K1R9V6

References