Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1546046..1546622 Replicon chromosome
Accession NZ_CP068159
Organism Corynebacterium riegelii strain FDAARGOS_1114

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag I6I71_RS07295 Protein ID WP_201819888.1
Coordinates 1546046..1546327 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6I71_RS07300 Protein ID WP_187400298.1
Coordinates 1546314..1546622 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I71_RS07265 1541469..1542473 + 1005 WP_201819859.1 NAD(P)/FAD-dependent oxidoreductase -
I6I71_RS07270 1542505..1544397 - 1893 WP_201819860.1 cadmium-translocating P-type ATPase -
I6I71_RS07275 1544394..1544753 - 360 WP_201819861.1 metalloregulator ArsR/SmtB family transcription factor -
I6I71_RS07280 1544970..1545320 - 351 WP_201819862.1 VOC family protein -
I6I71_RS07285 1545421..1545663 - 243 WP_201819863.1 toxin -
I6I71_RS07290 1545666..1545911 - 246 WP_201819876.1 ribbon-helix-helix domain-containing protein -
I6I71_RS07295 1546046..1546327 + 282 WP_201819888.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6I71_RS07300 1546314..1546622 + 309 WP_187400298.1 HigA family addiction module antidote protein Antitoxin
I6I71_RS07305 1546828..1547247 - 420 WP_201819890.1 hypothetical protein -
I6I71_RS07315 1548969..1549475 + 507 WP_187400300.1 SMI1/KNR4 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1532970..1555375 22405


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10966.47 Da        Isoelectric Point: 10.6580

>T186801 WP_201819888.1 NZ_CP068159:1546046-1546327 [Corynebacterium riegelii]
MIQSFANKDTERLWNRERVPSIDSRIHSVALRKLRQLGYAQSLQELRIPPGNRLEALKGDRRGQHSIRINSQWRICFRWT
AAGPEEVEIVDYH

Download         Length: 282 bp

>T186801 NZ_CP089772:c3071472-3071077 [Mycobacterium tuberculosis]
GTGATCGTCGATACGTCGGCCATCGTCGCCATCGTGAGCGGGGAATCGGGCGCGCAGGTGCTCAAGGAGGCGCTGGAGCG
GTCACCGAACTCCCGAATGTCCGCGCCCAACTACGTCGAACTGTGCGCGATCATGCAGCGGCGGGACCGGCCGGAGATCT
CTCGATTGGTGGACCGTTTGCTGGACGACTACGGAATCCAGGTCGAAGCCGTCGACGCCGACCAAGCCCGCGTGGCCGCG
CAGGCGTATCGCGACTACGGCCGCGGCAGCGGCCATCCGGCCCGTCTCAACCTCGGCGACACCTACAGCTACGCCCTGGC
CCAGGTCACCGGGGAGCCGCTGCTGTTTCGTGGCGATGACTTCACGCATACCGATATCCGGCCCGCGTGCACCTGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11381.19 Da        Isoelectric Point: 5.0981

>AT186801 WP_187400298.1 NZ_CP068159:1546314-1546622 [Corynebacterium riegelii]
MTITDKLPPVHPGEILMEDFLEEMGITQHKLAVSIGVPPRRINEIVHGKRAVTADTALRLGKYFGMSPQFWLGLQTQYDL
DVAEDKILAEIERIQPLQAASA

Download         Length: 309 bp

>AT186801 NZ_CP089772:c3071051-3070785 [Mycobacterium tuberculosis]
ATGCATCGCGGATATGCATTAGTAGTATGCTCTCCGGGTGTGACGCGCACCATGATCGACATCGATGACGACCTGCTCGC
TCGGGCCGCCAAGGAACTGGGTACCACGACAAAGAAAGACACCGTGCATGCCGCGCTGCGGGCCGCGTTGCGAGCCAGTG
CCGCGCGCTCGCTCATGAACCGGATGGCCGAGAACGCCACCGGAACCCAGGACGAAGCTCTGGTCAACGCAATGTGGCGA
GACGGCCACCCAGAGAACACGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References