Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2909826..2910553 Replicon chromosome
Accession NZ_CP068155
Organism Escherichia coli strain FDAARGOS_1077

Toxin (Protein)


Gene name higB Uniprot ID U9ZMR4
Locus tag I6I34_RS15210 Protein ID WP_000550189.1
Coordinates 2909826..2910140 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6I34_RS15215 Protein ID WP_000560266.1
Coordinates 2910137..2910553 (+) Length 139 a.a.

Genomic Context

I6I34_RS15205I6I34_RS15210I6I34_RS15215I6I34_RS15190I6I34_RS15195I6I34_RS15200I6I34_RS15220I6I34_RS15225
Location: 2908406..2909542 (1137 bp)
Type: Others
Protein ID: WP_000018695.1
Location: 2909826..2910140 (315 bp)
Type: Toxin
Protein ID: WP_000550189.1
Location: 2910137..2910553 (417 bp)
Type: Antitoxin
Protein ID: WP_000560266.1
Location: 2905984..2906970 (987 bp)
Type: Others
Protein ID: WP_000617698.1
Location: 2907049..2907741 (693 bp)
Type: Others
Protein ID: WP_000942548.1
Location: 2907818..2908321 (504 bp)
Type: Others
Protein ID: WP_001333820.1
Location: 2910598..2912616 (2019 bp)
Type: Others
Protein ID: WP_000121433.1
Location: 2912842..2915193 (2352 bp)
Type: Others
Protein ID: WP_000695470.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6I34_RS151902905984..2906970-987WP_000617698.1Gfo/Idh/MocA family oxidoreductase-
I6I34_RS151952907049..2907741-693WP_000942548.1vancomycin high temperature exclusion protein-
I6I34_RS152002907818..2908321-504WP_001333820.1M48 family metallopeptidase-
I6I34_RS152052908406..2909542+1137WP_000018695.123S rRNA (guanine(1835)-N(2))-methyltransferase RlmG-
I6I34_RS152102909826..2910140+315WP_000550189.1type II toxin-antitoxin system toxin HigBToxin
I6I34_RS152152910137..2910553+417WP_000560266.1type II toxin-antitoxin system antitoxin HigAAntitoxin
I6I34_RS152202910598..2912616-2019WP_000121433.1NADPH-dependent 2,4-dienoyl-CoA reductase-
I6I34_RS152252912842..2915193-2352WP_000695470.1alpha-glucosidase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12103.10 Da        Isoelectric Point: 10.0409

>T186783 WP_000550189.1 NZ_CP068155:2909826-2910140 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK

Download         Length: 315 bp

>T186783 NZ_CP089772:c2196031-2195702 [Mycobacterium tuberculosis]
GTGACCGCACTTCCGGCGCGCGGAGAGGTGTGGTGGTGTGAGATGGCTGAGATCGGTCGGCGACCAGTCGTCGTGCTGTC
GCGCGATGCCGCGATCCCTCGGCTGCGACGCGCACTTGTCGCGCCCTGCACCACGACCATCCGAGGGCTAGCCAGTGAGG
TTGTTCTTGAACCCGGTTCCGACCCGATCCCGCGCCGTTCCGCGGTGAATTTGGACTCAGTCGAAAGTGTCTCGGTCGCG
GTATTGGTGAATCGGCTTGGCCGCCTCGCCGACATCCGGATGCGCGCCATCTGCACGGCCCTCGAGGTCGCCGTCGATTG
CTCTCGATGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 14995.42 Da        Isoelectric Point: 4.4547

>AT186783 WP_000560266.1 NZ_CP068155:2910137-2910553 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID

Download         Length: 417 bp

>AT186783 NZ_CP089772:c2196405-2196028 [Mycobacterium tuberculosis]
GTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCG
TATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGA
GCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAG
GCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGA
TGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
PDB6KMQ
PDB5IFG
PDB5YCL
PDB6KML

Antitoxin

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Source
ID
Structure
No matching records found

References