Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yafN-yafO (relBE)/YafO-YafN
Location 1121316..1122010 Replicon chromosome
Accession NZ_CP068155
Organism Escherichia coli strain FDAARGOS_1077

Toxin (Protein)


Gene name yafO Uniprot ID S1EXB8
Locus tag I6I34_RS06605 Protein ID WP_001263493.1
Coordinates 1121316..1121714 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name yafN Uniprot ID S1FJN6
Locus tag I6I34_RS06610 Protein ID WP_000554757.1
Coordinates 1121717..1122010 (-) Length 98 a.a.

Genomic Context

I6I34_RS06585I6I34_RS06575----I6I34_RS06580I6I34_RS06590I6I34_RS06595I6I34_RS06600I6I34_RS06605I6I34_RS06610I6I34_RS06615I6I34_RS06620I6I34_RS06625I6I34_RS06630I6I34_RS06635
Location: 1118371..1119828 (1458 bp)
Type: Others
Protein ID: WP_001293003.1
Location: 1116316..1117560 (1245 bp)
Type: Others
Protein ID: WP_000189541.1
Location: 1116976..1117056 (81 bp)
Type: Others
Protein ID: NuclAT_12
Location: 1116976..1117056 (81 bp)
Type: Others
Protein ID: NuclAT_12
Location: 1116976..1117056 (81 bp)
Type: Others
Protein ID: NuclAT_12
Location: 1116976..1117056 (81 bp)
Type: Others
Protein ID: NuclAT_12
Location: 1117652..1118110 (459 bp)
Type: Others
Protein ID: WP_001291990.1
Location: 1119885..1120406 (522 bp)
Type: Others
Protein ID: Protein_1100
Location: 1120405..1120608 (204 bp)
Type: Others
Protein ID: Protein_1101
Location: 1120854..1121306 (453 bp)
Type: Others
Protein ID: WP_001059847.1
Location: 1121316..1121714 (399 bp)
Type: Toxin
Protein ID: WP_001263493.1
Location: 1121717..1122010 (294 bp)
Type: Antitoxin
Protein ID: WP_000554757.1
Location: 1122062..1123117 (1056 bp)
Type: Others
Protein ID: WP_001226164.1
Location: 1123188..1124111 (924 bp)
Type: Others
Protein ID: WP_001232570.1
Location: 1124114..1124977 (864 bp)
Type: Others
Protein ID: WP_001169518.1
Location: 1124990..1125709 (720 bp)
Type: Others
Protein ID: WP_000938740.1
Location: 1125729..1126196 (468 bp)
Type: Others
Protein ID: WP_000725257.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
I6I34_RS065751116316..1117560-1245WP_000189541.1esterase FrsA-
-1116976..1117056-81NuclAT_12--
-1116976..1117056-81NuclAT_12--
-1116976..1117056-81NuclAT_12--
-1116976..1117056-81NuclAT_12--
I6I34_RS065801117652..1118110-459WP_001291990.1xanthine phosphoribosyltransferase-
I6I34_RS065851118371..1119828+1458WP_001293003.1cytosol nonspecific dipeptidase-
I6I34_RS065901119885..1120406-522Protein_1100peptide chain release factor H-
I6I34_RS065951120405..1120608-204Protein_1101RNA ligase RtcB family protein-
I6I34_RS066001120854..1121306-453WP_001059847.1GNAT family N-acetyltransferase-
I6I34_RS066051121316..1121714-399WP_001263493.1type II toxin-antitoxin system mRNA interferase toxin YafOToxin
I6I34_RS066101121717..1122010-294WP_000554757.1type I toxin-antitoxin system antitoxin YafNAntitoxin
I6I34_RS066151122062..1123117-1056WP_001226164.1DNA polymerase IV-
I6I34_RS066201123188..1124111-924WP_001232570.1putative lateral flagellar export/assembly protein LafU-
I6I34_RS066251124114..1124977-864WP_001169518.1flagellar motor stator protein MotA-
I6I34_RS066301124990..1125709-720WP_000938740.1FliA/WhiG family RNA polymerase sigma factor-
I6I34_RS066351125729..1126196-468WP_000725257.1flagellar basal body-associated FliL family protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin YafO

(27-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15472.83 Da        Isoelectric Point: 8.0949

>T186777 WP_001263493.1 NZ_CP068155:c1121714-1121316 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF

Download         Length: 399 bp

>T186777 NZ_CP089772:1541675-1542496 [Mycobacterium tuberculosis]
GTGGTGGTAGCCCTCGTAGGCTCAGCAATCGTGGACTTGCATTCACGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
TGGCGTGGCACTGCGCGACGGAGTTGACCCGCCGGTCGACTGCCCGTCGTACGCCGAGGTGATGCTGTGGCATGCGGACT
TGGCCGCCGAAGTCCAGGACCGGATCGAGGGCCGGAGTTGGTCTGCGTCGGAGTTATTGGTTACCTCACGTGCGAAGAGC
CAAGACACCCTGCTAGCAAAGCTGCGGCGTCGGCCTTACCTGCAACTGAACACCATCCAAGACATCGCAGGTGTCCGCAT
CGATGCCGACCTCCTGCTGGGCGAGCAGACGAGACTTGCTCGCGAGATCGCCGACCACTTCGGTGCTGACCAGCCCGCTA
TTCATGATCTGCGTGACCACCCGCACGCCGGCTACCGGGCCGTTCATGTCTGGCTTCGGTTACCTGCCGGTCGTGTCGAG
ATACAGATTCGCACCATTTTGCAGAGCCTGTGGGCCAACTTCTACGAGCTTCTCGCTGACGCGTACGGTCGGGGCATCCG
CTATGACGAGCGGCCGGAGCAGCTAGCGGCCGGCGTTGTCCCGGCACAGCTTCAAGAGCTGGTAGGGGTTATGCAAGACG
CTTCAGCGGATCTGGCGATGCATGAAGCCGAGTGGCAACACTGTGCAGAGATCGAATACCCCGGCCAGCGGGCGATGGCG
CTTGGCGAGGCGAGCAAGAACAAGGCGACGGTGCTCGCAACGACCAAGTTTAGGCTGGAAAGGGCCATCAATGAGGCCGA
GTCGGCAGGGGGAGGTGGGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11233.81 Da        Isoelectric Point: 5.9050

>AT186777 WP_000554757.1 NZ_CP068155:c1122010-1121717 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE

Download         Length: 294 bp

>AT186777 NZ_CP089772:1542489-1542725 [Mycobacterium tuberculosis]
GTGGGTGAGGTGGCTGGCTATGTCGTCGAATACAACCGGCGCACCCACGTGCGTCGCATCACCGAGTTCGCCACCCCGCA
AGAAGCGATGGAGCACCGGTTGAAGCTGGAAGCCGAGCGCACCGACAGCAATATCGAGATCGTTGCGCTCGTCAGTAAGT
CGTTGGGAACCCTGAAGCAAACGCATTCGCGGTACTTCACTGGTGAAGAGCTGAACGTCGGAAACGGCGCGCGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBS1EXB8

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBS1FJN6

References