Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 5355765..5356270 Replicon chromosome
Accession NZ_CP068151
Organism Pseudomonas fluorescens strain FDAARGOS_1088

Toxin (Protein)


Gene name yoeB Uniprot ID A0A0W0MVT7
Locus tag I6I45_RS24365 Protein ID WP_014719853.1
Coordinates 5355765..5356019 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID I4K3F7
Locus tag I6I45_RS24370 Protein ID WP_003194039.1
Coordinates 5356016..5356270 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I45_RS24345 5351364..5352614 + 1251 WP_014719857.1 ATP-grasp domain-containing protein -
I6I45_RS24350 5352614..5353816 + 1203 WP_019817486.1 MFS transporter -
I6I45_RS24355 5353818..5354939 + 1122 WP_201914309.1 aminotransferase class V-fold PLP-dependent enzyme -
I6I45_RS24360 5354950..5355666 - 717 WP_201914312.1 hypothetical protein -
I6I45_RS24365 5355765..5356019 - 255 WP_014719853.1 Txe/YoeB family addiction module toxin Toxin
I6I45_RS24370 5356016..5356270 - 255 WP_003194039.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
I6I45_RS24375 5356415..5357668 - 1254 WP_201914315.1 aspartate aminotransferase family protein -
I6I45_RS24380 5357779..5358792 - 1014 WP_019817488.1 sensor domain-containing diguanylate cyclase -
I6I45_RS24385 5358931..5360832 - 1902 WP_019817489.1 alkaline phosphatase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9977.51 Da        Isoelectric Point: 8.0456

>T186763 WP_014719853.1 NZ_CP068151:c5356019-5355765 [Pseudomonas fluorescens]
MKILFTPEGWDDYLWFQQNDKAGLKRINLLIKAIQRDPFGGVGKPEPLKHNLSGFWSRRITAEHRLVYGIEDDEVQILMC
RYHY

Download         Length: 255 bp

>T186763 NZ_CP089772:712393-712794 [Mycobacterium tuberculosis]
GTGACGGTGCTGCTCGACGCCAACGTGCTGATCGCATTGGTGGTCGCCGAGCATGTGCATCATGATGCCGCAGCGGACTG
GCTCATGGCGTCCGACACCGGATTTGCGACCTGCCCGATGACACAAGGAAGCCTGGTTCGATTCCTGGTGCGCTCGGGAC
AGTCCGCGGCGGCGGCTCGGGATGTCGTCAGTGCGGTCCAGTGCACGAGCCGCCACGAATTCTGGCCCGATGCACTCTCT
TTCGCCGGTGTCGAGGTCGCTGGTGTGGTTGGGCACCGGCAGGTGACCGATGCCTACCTTGCCCAGCTCGCGCGAAGCCA
CGACGGGCAGTTGGCGACGCTCGACAGCGGCTTAGCACACCTGCACGGCGACGTCGCGGTACTCATTCCAACGACCACCT
GA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9576.93 Da        Isoelectric Point: 7.2034

>AT186763 WP_003194039.1 NZ_CP068151:c5356270-5356016 [Pseudomonas fluorescens]
METINYTNARAHLSETMDRVNDDHVPLLLTRQKGEPVVMISLSEFNALEETAYLLRSPKNAERLINSVNSLRAGKAKPRR
LIEE

Download         Length: 255 bp

>AT186763 NZ_CP089772:712169-712396 [Mycobacterium tuberculosis]
GTGCGCACTACCATCGACCTGCCGCAAGACCTGCACAAGCAGGCACTGGCGATTGCCCGGGATACGCACCGCACGTTGAG
TGAAACGGTCGCCGACCTCATGCGACGAGGCCTGGCCGCCAACCGCCCTACCGCGTTGTCCTCAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTCGGGACCGTCGTGACCTCCGAGGACGTGCGTTCATTAGAGGACGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0MVT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0MVN5

References