Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2522098..2522702 Replicon chromosome
Accession NZ_CP068151
Organism Pseudomonas fluorescens strain FDAARGOS_1088

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6I45_RS11340 Protein ID WP_020301040.1
Coordinates 2522098..2522412 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6I45_RS11345 Protein ID WP_014717446.1
Coordinates 2522415..2522702 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I45_RS11320 2517145..2518197 - 1053 WP_020301042.1 histone deacetylase family protein -
I6I45_RS11325 2518332..2519564 - 1233 WP_019818457.1 Zn-dependent hydrolase -
I6I45_RS11330 2519576..2520892 - 1317 WP_201915483.1 MHS family MFS transporter -
I6I45_RS11335 2521050..2521991 + 942 WP_014717448.1 LysR family transcriptional regulator -
I6I45_RS11340 2522098..2522412 + 315 WP_020301040.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6I45_RS11345 2522415..2522702 + 288 WP_014717446.1 helix-turn-helix domain-containing protein Antitoxin
I6I45_RS11350 2522947..2524173 + 1227 WP_014717445.1 MFS transporter -
I6I45_RS11355 2524247..2524501 - 255 WP_019818461.1 hypothetical protein -
I6I45_RS11360 2524908..2525147 + 240 WP_103451386.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
I6I45_RS11365 2525137..2525420 + 284 Protein_2240 type II toxin-antitoxin system RelE/ParE family toxin -
I6I45_RS11375 2525689..2526402 - 714 WP_005786030.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
I6I45_RS11380 2526430..2527188 - 759 WP_014717370.1 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11675.44 Da        Isoelectric Point: 10.0575

>T186760 WP_020301040.1 NZ_CP068151:2522098-2522412 [Pseudomonas fluorescens]
MIFIETSVFTRRVKELINEDAYTAFQNVLVVNPAAGDVIEGTGGIRKIRVAAKSHGKRGGARVIYYHFASASQIVLLMIY
PKNEQQDLSADERKSLKAAIEHWR

Download         Length: 315 bp

>T186760 NZ_CP089772:c696618-696226 [Mycobacterium tuberculosis]
GTGAACGTACGGCGCGCCCTCGCCGACACATCCGTTTTCATTGGCATCGAGGCGACACGATTCGACCCGGACCGGTTTGC
GGGATACGAATGGGGCGTCTCGGTAGTCACACTCGGCGAGCTGCGGCTCGGGGTGTTGCAAGCCTCCGGCCCCGAGGCCG
CCGCACGTCGGCTCTCCACCTACCAGCTTGCGCAACGGTTCGAACCACTAGGCATCGACGAGGCGGTCTCCGAAGCATGG
GCATTACTGGTGTCCAAGCTGCGCGCCGCCAAACTGCGCGTGCCGATCAACGACAGCTGGATTGCGGCCACAGCCGTGGC
GCACGGCATTGCGATCCTGACCCAAGACAACGACTACGCCGCCATGCCCGACGTCGAGGTCATAACGATCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10794.39 Da        Isoelectric Point: 7.3219

>AT186760 WP_014717446.1 NZ_CP068151:2522415-2522702 [Pseudomonas fluorescens]
MSRLFDELMESVQEMNEILRGEREPSREFHVDSMRVKEIRKATGLTQAKFAALIDVQLGTLRNWEQGRREPTGPAKALLK
AIHNDPVHVLNALAS

Download         Length: 288 bp

>AT186760 NZ_CP089772:c696872-696615 [Mycobacterium tuberculosis]
ATGTCTGCTACGATACCCGCTCGCGATCTTCGCAACCACACCGCCGAGGTACTGCGGCGAGTTGCCGCCGGCGAGGAAAT
CGAGGTGCTCAAGGACAATCGCCCCGTAGCGCGCATCGTTCCGCTCAAGCGGCGCCGCCAATGGTTGCCAGCTGCCGAGG
TGATCGGCGAACTGGTGCGCTTGGGCCCCGATACCACCAATCTGGGCGAGGAGCTGCGAGAGACGCTGACGCAAACCACG
GACGATGTGCGGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References