Detailed information of TA system TA186758

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 542916..543570
• Replicon: chromosome
• Accession: NZ_CP068151
• Organism: Pseudomonas fluorescens strain FDAARGOS_1088

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: I6I45_RS02585
• Protein ID: WP_038450524.1
• Coordinates: 543220..543570 (-)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A0W0N117
• Locus tag: I6I45_RS02580
• Protein ID: WP_014718915.1
• Coordinates: 542916..543230 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I45_RS02545	538845..539705	+	861	WP_201914777.1	Dyp-type peroxidase	-
I6I45_RS02550	539736..540257	-	522	WP_201914779.1	DUF3087 family protein	-
I6I45_RS02555	540372..540551	+	180	WP_014718919.1	hypothetical protein	-
I6I45_RS02560	540564..540758	+	195	WP_005789138.1	hypothetical protein	-
I6I45_RS02565	540789..541025	-	237	WP_014718918.1	hypothetical protein	-
I6I45_RS02570	541146..541979	+	834	WP_072433921.1	arylamine N-acetyltransferase	-
I6I45_RS02575	542105..542857	+	753	WP_014718916.1	outer membrane beta-barrel protein	-
I6I45_RS02580	542916..543230	-	315	WP_014718915.1	XRE family transcriptional regulator	Antitoxin
I6I45_RS02585	543220..543570	-	351	WP_038450524.1	hypothetical protein	Toxin
I6I45_RS02590	543808..545271	-	1464	WP_003174731.1	NADH-quinone oxidoreductase subunit NuoN	-
I6I45_RS02595	545279..546811	-	1533	WP_014718913.1	NADH-quinone oxidoreductase subunit M	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 13790.82 Da
• Isoelectric Point: 9.8857

>T186758 WP_038450524.1 NZ_CP068151:c543570-543220 [Pseudomonas fluorescens]
MDALFIELPAFERYRKDYLSDELFQGFQQELMKNPEAGDVIEGTGGLRKVRFIDERRNKGKRGGLRVIYYWWSGGTQFWL
FTLYGKHEQNDLAPQHKKALKHMLVREIKARMHNET

Nucleotide

• Length: 351 bp

>T186758 NZ_CP089772:c642037-641624 [Mycobacterium tuberculosis]
GTGAGAGCATCGCCCACTTCGCCGCCGGAGCAGGTGGTCGTCGACGCGAGTGCCATGGTGGATCTACTGGCTCGCACTAG
CGATCGGTGCTCTGCGGTGCGCGCGCGGCTGGCTCGGACCGCGATGCACGCGCCGGCGCACTTCGATGCAGAGGTGTTGT
CGGCGCTGGGGCGCATGCAGCGCGCCGGCGCACTCACCGTTGCCTATGTCGATGCGGCACTGGAGGAGTTGCGACAGGTG
CCGGTGACTCGACACGGTCTTTCGTCGCTGCTTGCTGGAGCGTGGTCGCGCCGCGACACCCTCCGCCTGACCGATGCCCT
CTACGTCGAGCTGGCCGAAACGGCAGGTCTGGTGTTGTTGACCACCGACGAAAGATTGGCACGCGCCTGGCCCTCGGCTC
ACGCCATCGGCTGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11755.58 Da
• Isoelectric Point: 10.6525

>AT186758 WP_014718915.1 NZ_CP068151:c543230-542916 [Pseudomonas fluorescens]
MKRDIFSELVEGFDALADERQGKITLRNHKVHLNKLAPLTADEVIAVRQQLNLSRSVFAMYLRTNTRTLENWEQGRAKPN
AQAVTLIRLVARFPETVAQLAALG

Nucleotide

• Length: 315 bp

>AT186758 NZ_CP089772:c642300-642034 [Mycobacterium tuberculosis]
TTGTTGAGCCGGCGCACGAAAACGATCGTTGTGTGTACATTGGTGTGTATGGCTCGGTTGAACGTGTATGTGCCCGACGA
ATTGGCGGAGCGCGCCAGGGCGCGGGGCTTGAACGTCTCGGCGCTGACTCAGGCCGCGATCAGTGCCGAGTTGGAGAACT
CCGCAACCGATGCGTGGCTTGAGGGGTTGGAACCCAGAAGCACCGGCGCTCGGCATGATGACGTGCTGGGTGCGATCGAT
GCCGCTCGCGATGAGTTCGAAGCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0W0N117