Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4618888..4619541 Replicon chromosome
Accession NZ_CP068148
Organism Serratia liquefaciens strain FDAARGOS_1081

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6I38_RS21545 Protein ID WP_201895778.1
Coordinates 4619191..4619541 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6I38_RS21540 Protein ID WP_128865536.1
Coordinates 4618888..4619187 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I38_RS21520 4614662..4615057 - 396 WP_020825052.1 hypothetical protein -
I6I38_RS21525 4615138..4615992 + 855 WP_201895776.1 helix-turn-helix transcriptional regulator -
I6I38_RS21530 4616050..4617186 - 1137 WP_201895777.1 porin -
I6I38_RS21535 4617774..4618850 + 1077 WP_048762869.1 YncE family protein -
I6I38_RS21540 4618888..4619187 - 300 WP_128865536.1 helix-turn-helix transcriptional regulator Antitoxin
I6I38_RS21545 4619191..4619541 - 351 WP_201895778.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6I38_RS21550 4619642..4619956 - 315 WP_201895779.1 hypothetical protein -
I6I38_RS21555 4620215..4621594 + 1380 WP_201895780.1 glutamine synthetase family protein -
I6I38_RS21560 4621628..4622338 + 711 WP_201895781.1 trehalose-6-phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13491.53 Da        Isoelectric Point: 6.7126

>T186754 WP_201895778.1 NZ_CP068148:c4619541-4619191 [Serratia liquefaciens]
MWTVITTEEFDRWFVSQDDLTQEKVLAALVMLERGGPNLSRPFVDSLKESQHSNMKELRIQHKGRPIRAFFAFDPVRQAI
VLCAGDKTGNEKRFYKVMLPIADAQFTQHLMCNFEE

Download         Length: 351 bp

>T186754 NZ_CP089772:367410-367712 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11172.86 Da        Isoelectric Point: 5.2187

>AT186754 WP_128865536.1 NZ_CP068148:c4619187-4618888 [Serratia liquefaciens]
MGTLKEMLASRTPDSRQRIEEMAEEMLLETRLYEVREALDISQQTLANKLGISQPSVAAIEQRGNELKISTLKRYVEAMG
GTLRLDIELPDGKHVGFRV

Download         Length: 300 bp

>AT186754 NZ_CP089772:367186-367413 [Mycobacterium tuberculosis]
ATGACGAAAGAGAAGATCTCCGTGACGGTGGACGCGGCCGTCCTCGCGGCGATCGACGCGGACGCCAGGGCGGCGGGTTT
GAATCGGTCGGAAATGATTGAGCAGGCACTGCGCAACGAGCACCTGCGTGTCGCTCTGCGCGATTACACGGCTAAAACCG
TACCGGCGTTGGACATCGATGCCTACGCACAGCGGGTGTACCAGGCGAACCGGGCGGCCGGAAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References