Detailed information of TA system TA186741

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 849140..849792
• Replicon: chromosome
• Accession: NZ_CP068148
• Organism: Serratia liquefaciens strain FDAARGOS_1081

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: I6I38_RS03840
• Protein ID: WP_142814507.1
• Coordinates: 849448..849792 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A515CQP0
• Locus tag: I6I38_RS03835
• Protein ID: WP_020828411.1
• Coordinates: 849140..849442 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I38_RS03815	844427..845335	+	909	WP_020828415.1	LysR family transcriptional regulator	-
I6I38_RS03820	845653..846807	+	1155	WP_046372746.1	MFS transporter	-
I6I38_RS03825	846797..847720	-	924	WP_201896047.1	LysR family transcriptional regulator	-
I6I38_RS03830	847847..849109	+	1263	WP_122080104.1	diaminopimelate decarboxylase	-
I6I38_RS03835	849140..849442	-	303	WP_020828411.1	helix-turn-helix transcriptional regulator	Antitoxin
I6I38_RS03840	849448..849792	-	345	WP_142814507.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6I38_RS03845	849932..850942	-	1011	WP_142814508.1	LacI family DNA-binding transcriptional regulator	-
I6I38_RS03850	851094..851549	+	456	WP_122080102.1	GNAT family N-acetyltransferase	-
I6I38_RS03855	851546..852565	-	1020	WP_020828407.1	HTH-type transcriptional regulator GalR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-105)

Antitoxin

• HigA2-like, helix-turn-helix domain (21-89)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13491.61 Da
• Isoelectric Point: 10.8313

>T186741 WP_142814507.1 NZ_CP068148:c849792-849448 [Serratia liquefaciens]
MWQIVTVERFDSWFLSLNSDQQKSVLVGIFKLQEFGPLLARPHADTLNHKNQIQHLKELRIQHRGRPFRIFFAFDPQRQA
ALLCGGDKTGNKRFYQQMLPIAIREFPHYLATQR

Nucleotide

• Length: 345 bp

>T186741 NZ_CP089769:116603-117073 [Klebsiella pneumoniae]
GTGATCCTCTACAGGCTGACGAAAACAAAGTATCTTTCTACGGCATGGACCGGATATGGTGCGAAAGAGGCTGGTGGACG
CTGGAATAGCGTGGGGGTGTCAATGGTATATGTCTCCGAAACGGCATCACTAACGATGCTGGAGACGCTGGTACACCTGC
ATGCGGCACAGATAATGGACTCTTTCACGCTACTGAGTATCGATGTGCCTGATGAACTGATCCAAAGCGCAAACATGGAT
GAATTACCGGACAACTGGGCTGATGAGGATGCGCCTCAGGAACTGGCTGATTACGGAGATGCCTGGTCATTTACCAGGAG
CTCGGTTGCACTGCGTGTTCCCTCAGCCTTATCGCCGGTAGAGTTCAATTATCTGTTAAATCCTGAGCACCCTGAGTTTT
ACGGGATCGTGCAGAAGGCTCAACAGATACCGTTCCGGTTTGATAGTCGTCTTAAACCTGACAGGAAGTGA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11170.02 Da
• Isoelectric Point: 8.6182

>AT186741 WP_020828411.1 NZ_CP068148:c849442-849140 [Serratia liquefaciens]
MAKPLSDLIDRLDPTVVEAAQQKADKEIFELRLAMLREELAVSQVELAKRLGISQPSVANLEKRGSEIKLSSLKRYIEAM
GGTLSLEVQLPNGQHRRMTL

Nucleotide

• Length: 303 bp

>AT186741 NZ_CP089769:116163-116606 [Klebsiella pneumoniae]
ATGAAAACATTTAGTTTGTCCTCAACTCCAGCCAGACCACAGCGCCTCTGGCAGGTTGCCGGGTTAAATAATGCTGATGG
CGTAGCGCTTCTGGGCCAAATCAATGAAGGCCTTGACGGGAAGGTGGCGAACCGGATCACTGACTGGGCCAGAATAACCC
AGAATGACCTGAGAAAAATGTCCGGTATCCCGTCGACCACATTTAGCCGCAGTGTGAAGGCACGTTTTAACCCTGAACAA
AGTGAACGTCTGGTACGTATTATCCGCGTCATTGATCGGGCGGTAGATTTGTTTGAAGGCGACAAGGAAGCCGCACAGAA
GTGGTTGAACGAACCTAACCGGGCATTGAGCTGGAAAGTGCCAGCAGACCTGATGGCATCCGAGACGGGAGCGTATGAGA
TCATTAAGCTGATTACGCGTCTGGAGCATGGGGTGTACTCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A515CQP0