Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3640031..3640576 Replicon chromosome
Accession NZ_CP068147
Organism Yersinia enterocolitica strain FDAARGOS_1090

Toxin (Protein)


Gene name yafQ Uniprot ID A0A7T9XU23
Locus tag I6I47_RS16395 Protein ID WP_005161463.1
Coordinates 3640298..3640576 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A7T9Y052
Locus tag I6I47_RS16390 Protein ID WP_005161466.1
Coordinates 3640031..3640291 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I47_RS16350 3635192..3636367 - 1176 WP_020282718.1 phage tail sheath protein -
I6I47_RS16355 3636677..3636862 - 186 WP_013649738.1 hypothetical protein -
I6I47_RS16360 3636996..3637134 - 139 Protein_3166 ash family protein -
I6I47_RS16365 3637426..3638310 - 885 WP_072077075.1 Rpn family recombination-promoting nuclease/putative transposase -
I6I47_RS16370 3638516..3638692 - 177 WP_005161476.1 hypothetical protein -
I6I47_RS16375 3639134..3639454 - 321 WP_005161473.1 hypothetical protein -
I6I47_RS16380 3639444..3639650 - 207 WP_013649742.1 hypothetical protein -
I6I47_RS16385 3639792..3639959 + 168 WP_005161469.1 hypothetical protein -
I6I47_RS16390 3640031..3640291 + 261 WP_005161466.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6I47_RS16395 3640298..3640576 + 279 WP_005161463.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
I6I47_RS16400 3640629..3641241 - 613 Protein_3174 tail fiber assembly protein -
I6I47_RS16405 3641241..3642534 - 1294 Protein_3175 phage tail protein -
I6I47_RS16410 3642778..3643332 - 555 WP_020283262.1 phage tail protein I -
I6I47_RS16415 3643325..3644233 - 909 WP_020283261.1 baseplate assembly protein -
I6I47_RS16420 3644238..3644588 - 351 WP_020283260.1 GPW/gp25 family protein -
I6I47_RS16425 3644585..3645220 - 636 WP_013649748.1 phage baseplate assembly protein V -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - pilW 3614965..3649068 34103


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 11002.70 Da        Isoelectric Point: 9.6243

>T186728 WP_005161463.1 NZ_CP068147:3640298-3640576 [Yersinia enterocolitica]
MTKQREIEYSGQFQKDVKKAQKRHKDINKLKTIMALLIDDKLPLPVIYKDHQLQGNYKGYRDAHIEPDWLIIYKITDDLL
RFERTGSHSDLF

Download         Length: 279 bp

>T186728 NZ_CP089768:382989-383399 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9277.75 Da        Isoelectric Point: 7.0134

>AT186728 WP_005161466.1 NZ_CP068147:3640031-3640291 [Yersinia enterocolitica]
MAANAFVRARIDETLKNEAAAVLAGMGLTVSDLVRITLTKVAREKALPFDLRIPNELTAKTIANSEKGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT186728 NZ_CP089768:382742-383008 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9XU23

Antitoxin

Source ID Structure
AlphaFold DB A0A7T9Y052

References