Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2556818..2557512 Replicon chromosome
Accession NZ_CP068147
Organism Yersinia enterocolitica strain FDAARGOS_1090

Toxin (Protein)


Gene name mqsR Uniprot ID A0A7U7FJ92
Locus tag I6I47_RS11430 Protein ID WP_005166025.1
Coordinates 2556818..2557114 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID A0A7U7IQA2
Locus tag I6I47_RS11435 Protein ID WP_005166024.1
Coordinates 2557114..2557512 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I47_RS11410 2551944..2553746 + 1803 WP_020282599.1 hypothetical protein -
I6I47_RS11415 2553806..2555053 - 1248 WP_020282600.1 tyrosine-type recombinase/integrase -
I6I47_RS11420 2555973..2556233 + 261 WP_005166028.1 type II toxin-antitoxin system RelE/ParE family toxin -
I6I47_RS11425 2556299..2556661 + 363 WP_005166026.1 helix-turn-helix domain-containing protein -
I6I47_RS11430 2556818..2557114 + 297 WP_005166025.1 type II toxin-antitoxin system MqsR family toxin Toxin
I6I47_RS11435 2557114..2557512 + 399 WP_005166024.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
I6I47_RS11440 2557619..2558821 - 1203 WP_005177049.1 IS256 family transposase -
I6I47_RS11445 2558970..2559170 - 201 WP_005166614.1 AlpA family transcriptional regulator -
I6I47_RS11450 2559188..2560023 + 836 Protein_2215 Fic family protein -
I6I47_RS11455 2560395..2560790 + 396 WP_020282601.1 SgcJ/EcaC family oxidoreductase -
I6I47_RS11460 2560873..2562117 + 1245 WP_005166619.1 sensor domain-containing diguanylate cyclase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(75-128)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11322.18 Da        Isoelectric Point: 7.7766

>T186726 WP_005166025.1 NZ_CP068147:2556818-2557114 [Yersinia enterocolitica]
MEKRTPHTRLLKVKELVLKGNVKSTRTARDGAEELGLSFRDMCDVVCELTSADFYKSMTTHQDHTIWQDVYRPMLSCGRV
YLKITVIDDVLIVSFKEL

Download         Length: 297 bp

>T186726 NZ_CP089767:c15016-14600 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACCAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATTGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCGTCCTGCCCTGGGACCGCGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAATGACACGGCCATTGC
CGGGCACGCCATCGCGGCGGGCGCCATCCTGGTGACGAACAATGTGAGAGAGTTTGCGCGGGTCCCGGGCCTGGTGCTGG
AAGACTGGGTGAAATAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14716.19 Da        Isoelectric Point: 8.8165

>AT186726 WP_005166024.1 NZ_CP068147:2557114-2557512 [Yersinia enterocolitica]
MMKCPVCGGAELIHEARDVPFTYKGRKFIVEGVIGQHCPACGETIMTEAESDTYAAKTMLLRKMVNTESIAPAYIVQVRK
KLGLNQREASEIFGGGVNAFSRYEKGKALPHRSTIKLLQVLDKYPELLNEIR

Download         Length: 399 bp

>AT186726 NZ_CP089767:c15243-15013 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGATGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7FJ92

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7IQA2

References