Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | DinJ-YafQ (relBE)/YafQ-RelB |
| Location | 4437139..4437684 | Replicon | chromosome |
| Accession | NZ_CP068146 | ||
| Organism | Yersinia enterocolitica strain FDAARGOS_1082 | ||
Toxin (Protein)
| Gene name | yafQ | Uniprot ID | A0A7T9XU23 |
| Locus tag | I6I39_RS19915 | Protein ID | WP_005161463.1 |
| Coordinates | 4437139..4437417 (-) | Length | 93 a.a. |
Antitoxin (Protein)
| Gene name | dinJ | Uniprot ID | A0A7T9Y052 |
| Locus tag | I6I39_RS19920 | Protein ID | WP_005161466.1 |
| Coordinates | 4437424..4437684 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6I39_RS19880 | 4432500..4433135 | + | 636 | WP_005161446.1 | phage baseplate assembly protein V | - |
| I6I39_RS19885 | 4433132..4433488 | + | 357 | WP_005161449.1 | GPW/gp25 family protein | - |
| I6I39_RS19890 | 4433488..4434396 | + | 909 | WP_005178623.1 | baseplate assembly protein | - |
| I6I39_RS19895 | 4434389..4434931 | + | 543 | WP_050124443.1 | phage tail protein I | - |
| I6I39_RS19900 | 4434928..4435209 | + | 282 | WP_005161459.1 | phage tail protein | - |
| I6I39_RS19905 | 4435182..4436474 | + | 1293 | WP_014608992.1 | phage tail protein | - |
| I6I39_RS19910 | 4436474..4437086 | + | 613 | Protein_3877 | tail fiber assembly protein | - |
| I6I39_RS19915 | 4437139..4437417 | - | 279 | WP_005161463.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | Toxin |
| I6I39_RS19920 | 4437424..4437684 | - | 261 | WP_005161466.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| I6I39_RS19925 | 4437756..4437923 | - | 168 | WP_005161469.1 | hypothetical protein | - |
| I6I39_RS19930 | 4438065..4438271 | + | 207 | WP_005161471.1 | hypothetical protein | - |
| I6I39_RS19935 | 4438261..4438581 | + | 321 | WP_005161473.1 | hypothetical protein | - |
| I6I39_RS19940 | 4439023..4439199 | + | 177 | WP_005161476.1 | hypothetical protein | - |
| I6I39_RS19945 | 4439405..4440289 | + | 885 | WP_072077259.1 | Rpn family recombination-promoting nuclease/putative transposase | - |
| I6I39_RS19950 | 4440581..4440719 | + | 139 | Protein_3885 | ash family protein | - |
| I6I39_RS19955 | 4440952..4441677 | - | 726 | WP_014608996.1 | IS21-like element ISYen2A/ISYen2B family helper ATPase IstB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | pilW | 4417519..4475675 | 58156 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 93 a.a. Molecular weight: 11002.70 Da Isoelectric Point: 9.6243
>T186719 WP_005161463.1 NZ_CP068146:c4437417-4437139 [Yersinia enterocolitica]
MTKQREIEYSGQFQKDVKKAQKRHKDINKLKTIMALLIDDKLPLPVIYKDHQLQGNYKGYRDAHIEPDWLIIYKITDDLL
RFERTGSHSDLF
MTKQREIEYSGQFQKDVKKAQKRHKDINKLKTIMALLIDDKLPLPVIYKDHQLQGNYKGYRDAHIEPDWLIIYKITDDLL
RFERTGSHSDLF
Download Length: 279 bp
>T186719 NZ_CP089765:1936098-1936481 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9277.75 Da Isoelectric Point: 7.0134
>AT186719 WP_005161466.1 NZ_CP068146:c4437684-4437424 [Yersinia enterocolitica]
MAANAFVRARIDETLKNEAAAVLAGMGLTVSDLVRITLTKVAREKALPFDLRIPNELTAKTIANSEKGVDVHKAKDADDL
FDKLGI
MAANAFVRARIDETLKNEAAAVLAGMGLTVSDLVRITLTKVAREKALPFDLRIPNELTAKTIANSEKGVDVHKAKDADDL
FDKLGI
Download Length: 261 bp
>AT186719 NZ_CP089765:1935856-1936098 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7T9XU23 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7T9Y052 |