Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1442335..1442837 Replicon chromosome
Accession NZ_CP068146
Organism Yersinia enterocolitica strain FDAARGOS_1082

Toxin (Protein)


Gene name yoeB Uniprot ID A0A7T9Y4I7
Locus tag I6I39_RS06290 Protein ID WP_005156563.1
Coordinates 1442335..1442589 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A7U7FIK7
Locus tag I6I39_RS06295 Protein ID WP_005156566.1
Coordinates 1442586..1442837 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I39_RS06280 1437424..1439556 - 2133 WP_005156559.1 TonB-dependent siderophore receptor -
I6I39_RS06285 1439975..1442311 + 2337 WP_005156561.1 mechanosensitive ion channel family protein -
I6I39_RS06290 1442335..1442589 - 255 WP_005156563.1 Txe/YoeB family addiction module toxin Toxin
I6I39_RS06295 1442586..1442837 - 252 WP_005156566.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
I6I39_RS06300 1442968..1445754 - 2787 WP_005156568.1 insulinase family protein -
I6I39_RS06305 1445739..1447484 - 1746 WP_005156574.1 ABC transporter ATP-binding protein/permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10097.60 Da        Isoelectric Point: 9.4486

>T186704 WP_005156563.1 NZ_CP068146:c1442589-1442335 [Yersinia enterocolitica]
VRIIFSSCSWEDYLYWQQTDKKILKRINELVKNIQRTPFEGKGKPEPLKHNLAGFWSRRITEEHRLVYEVSGDNLLIAAC
RYHY

Download         Length: 255 bp

>T186704 NZ_CP089762:1271501-1271603 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9447.66 Da        Isoelectric Point: 4.4878

>AT186704 WP_005156566.1 NZ_CP068146:c1442837-1442586 [Yersinia enterocolitica]
MRTISYSEARQNLSTTMVQTVEDRAPILITRQNGTSCVLMSLEEYESLEETAYLLRSPANAKHLMDSIEELRAGKGIQRE
LEE

Download         Length: 252 bp

>AT186704 NZ_CP089762:c1271610-1271465 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7T9Y4I7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U7FIK7

References