Detailed information of TA system TA186699

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 2887128..2887786
• Replicon: chromosome
• Accession: NZ_CP068145
• Organism: Morganella morganii strain FDAARGOS_1085

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A7T9XFK0
• Locus tag: I6I42_RS13745
• Protein ID: WP_024473887.1
• Coordinates: 2887433..2887786 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: J7TDD0
• Locus tag: I6I42_RS13740
• Protein ID: WP_004236876.1
• Coordinates: 2887128..2887430 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I42_RS13700	2883493..2884188	-	696	WP_024473885.1	MgtC family protein	-
I6I42_RS13705	2884539..2884733	-	195	WP_015422621.1	protein DsrB	-
I6I42_RS13710	2884837..2885049	-	213	WP_004240014.1	transcription antiterminator/RNA stability regulator CspE	-
I6I42_RS13715	2885510..2886019	+	510	WP_201893287.1	YlaC family protein	-
I6I42_RS13740	2887128..2887430	-	303	WP_004236876.1	XRE family transcriptional regulator	Antitoxin
I6I42_RS13745	2887433..2887786	-	354	WP_024473887.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6I42_RS13750	2888063..2889115	+	1053	WP_201893288.1	dihydroorotase	-
I6I42_RS13755	2889350..2889607	+	258	WP_024473889.1	biofilm formation regulator BssS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-81)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13648.63 Da
• Isoelectric Point: 9.9631

>T186699 WP_024473887.1 NZ_CP068145:c2887786-2887433 [Morganella morganii]
VWKIVTTDNFTVWFAEQDDGDRAAILAAMLVLEKRGPGLPRPYADTVKGSRYTNMKELRIQSRGQPIRAFFAFDPERRGV
LLCAGYKTGKEKRFYMQMIPQADREYTEWLNRPENRS

Nucleotide

• Length: 354 bp

>T186699 NZ_CP089745:3493024-3493602 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11108.00 Da
• Isoelectric Point: 9.5930

>AT186699 WP_004236876.1 NZ_CP068145:c2887430-2887128 [Morganella morganii]
MGKSLRQLLAEEKPEVAAAARVQADEILLNIHLAELREKVKKTQVEMAQALGIKQPTVAGMEKPGRDVKLSTLRRYVDAI
GGKLNIDVELPDGTHYMFRV

Nucleotide

• Length: 303 bp

>AT186699 NZ_CP089745:3492381-3492935 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA

Structures

Antitoxin

• AlphaFold DB: J7TDD0