Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2255071..2255719 Replicon chromosome
Accession NZ_CP068145
Organism Morganella morganii strain FDAARGOS_1085

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6I42_RS10590 Protein ID WP_024473062.1
Coordinates 2255071..2255415 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6I42_RS10595 Protein ID WP_024473063.1
Coordinates 2255420..2255719 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I42_RS10570 2250442..2251086 - 645 WP_024473058.1 homoserine/threonine efflux transporter -
I6I42_RS10575 2251215..2252303 + 1089 WP_201893175.1 efflux RND transporter periplasmic adaptor subunit -
I6I42_RS10580 2252300..2254739 + 2440 Protein_2050 efflux RND transporter permease subunit -
I6I42_RS10585 2254733..2254915 + 183 WP_024473061.1 hypothetical protein -
I6I42_RS10590 2255071..2255415 + 345 WP_024473062.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6I42_RS10595 2255420..2255719 + 300 WP_024473063.1 helix-turn-helix transcriptional regulator Antitoxin
I6I42_RS10600 2255773..2256645 - 873 WP_201893176.1 dimethyl sulfoxide reductase anchor subunit -
I6I42_RS10605 2256642..2257271 - 630 WP_201893177.1 dimethylsulfoxide reductase subunit B -
I6I42_RS10610 2257268..2259655 - 2388 WP_201893178.1 molybdopterin-dependent oxidoreductase -
I6I42_RS10615 2260064..2260270 - 207 WP_024473067.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13172.07 Da        Isoelectric Point: 9.3450

>T186698 WP_024473062.1 NZ_CP068145:2255071-2255415 [Morganella morganii]
VRTVLLTDYFNEWLSGQDTRMQEKVLASLGNLEIYGPVLTRPYVDTVKNSQYPNMKELRIWHAGRAIRAFFAFDSERQAI
VLCAGDKGKNKRFYQTMIRIADEQFSSYLAAAKE

Download         Length: 345 bp

>T186698 NZ_CP089745:1824397-1824984 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGTATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGTGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11208.05 Da        Isoelectric Point: 8.6587

>AT186698 WP_024473063.1 NZ_CP068145:2255420-2255719 [Morganella morganii]
MKTLQEVIAAQPPESRERIKRLTDELVLETGLQLLREELHISQKMLATNLGISQPAVTQIEQRGNDIKLATLKRYIEAMG
GTLRLTIELPTGDNRVFRV

Download         Length: 300 bp

>AT186698 NZ_CP089745:1825051-1825905 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAACAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGCTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGACAGCCTGGAAACCCAGACCCGCTGGCGTGAGACGGTGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGTGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGGCAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGCGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCATCCTTGACGATCTACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References