Detailed information of TA system TA186688

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF1/-
• Location: 773029..773367
• Replicon: chromosome
• Accession: NZ_CP068143
• Organism: Staphylococcus aureus strain FDAARGOS_1086

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: I6I43_RS03910
• Protein ID: WP_011447039.1
• Coordinates: 773029..773205 (+)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	773193..773367 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I43_RS03890	770859..771011	+	153	WP_001000058.1	hypothetical protein	-
I6I43_RS03895	771057..771344	+	288	WP_001262621.1	hypothetical protein	-
I6I43_RS03900	771400..771774	+	375	WP_000340977.1	hypothetical protein	-
I6I43_RS03905	772147..772920	+	774	WP_000750412.1	staphylococcal enterotoxin type A	-
I6I43_RS03910	773029..773205	+	177	WP_011447039.1	putative holin-like toxin	Toxin
-	773193..773367	-	175	-	-	Antitoxin
I6I43_RS03920	773417..773671	+	255	WP_000611512.1	phage holin	-
I6I43_RS03925	773683..774438	+	756	WP_000861038.1	CHAP domain-containing protein	-
I6I43_RS03930	774629..775120	+	492	WP_000920038.1	staphylokinase	-
I6I43_RS03935	775627..776946	-	1320	WP_001808146.1	ISL3-like element IS1181 family transposase	-
I6I43_RS03940	777295..777630	+	336	Protein_773	SH3 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	hlb / sea / sak / scn	731127..778491	47364
	-	flank	IS/Tn	-	-	775627..776946	1319

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T186688 WP_011447039.1 NZ_CP068143:773029-773205 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T186688 NZ_CP089742:2452385-2452636 [Melaminivora jejuensis]
ATGCACACCTGGCAAATGCAGACCGCCAAGGCGCGGTTTTCTGAGGTGGTCAAGCAAGCCGCCGATGACGGCCCGCAAGA
AATCACCGTGCATGGCCGCTCGGTGGCCGTGGTCATCTCCAAGGAGCTGTTTGACCGCCTCAGCGGCAACGAAGCCTCGC
TGGTGGACTTCATGCGCCAGTCCCCGCTGTACGGAGACGAGGACATCGCGTTCGAGCGCGACCGCAGCCTGGCGCGCGAG
GTGGACTTGTGA

Antitoxin

Nucleotide

• Length: 175 bp

>AT186688 NZ_CP068143:c773367-773193 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Structures

Toxin

• PDB: 7NS1

Antitoxin