Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 748159..748573 Replicon chromosome
Accession NZ_CP068143
Organism Staphylococcus aureus strain FDAARGOS_1086

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag I6I43_RS03740 Protein ID WP_025174939.1
Coordinates 748159..748410 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag I6I43_RS03745 Protein ID WP_000028424.1
Coordinates 748400..748573 (+) Length 58 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I43_RS03700 743865..744785 + 921 WP_000138475.1 recombinase RecT -
I6I43_RS03705 744866..745483 + 618 WP_071621397.1 MBL fold metallo-hydrolase -
I6I43_RS03710 745484..745954 + 471 WP_000934760.1 single-stranded DNA-binding protein -
I6I43_RS03715 745984..746877 + 894 WP_000148335.1 DnaD domain-containing protein -
I6I43_RS03720 746884..747102 + 219 WP_000338527.1 hypothetical protein -
I6I43_RS03725 747111..747515 + 405 WP_000401978.1 RusA family crossover junction endodeoxyribonuclease -
I6I43_RS03730 747528..747898 + 371 Protein_731 hypothetical protein -
I6I43_RS03735 747902..748144 + 243 WP_000131381.1 phi PVL orf 51-like protein -
I6I43_RS03740 748159..748410 + 252 WP_025174939.1 DUF1024 family protein Toxin
I6I43_RS03745 748400..748573 + 174 WP_000028424.1 hypothetical protein Antitoxin
I6I43_RS03750 748574..748855 + 282 WP_000454994.1 hypothetical protein -
I6I43_RS03755 748856..749017 + 162 WP_000889683.1 hypothetical protein -
I6I43_RS03760 749032..749565 + 534 WP_025920701.1 dUTP diphosphatase -
I6I43_RS03765 749602..749808 + 207 WP_000195826.1 DUF1381 domain-containing protein -
I6I43_RS03770 749805..749996 + 192 Protein_739 hypothetical protein -
I6I43_RS03775 749997..750200 + 204 WP_001072793.1 hypothetical protein -
I6I43_RS03780 750193..750318 + 126 WP_031783376.1 transcriptional regulator -
I6I43_RS03785 750318..750518 + 201 WP_001570807.1 DUF1514 family protein -
I6I43_RS03790 750541..751011 + 471 WP_000282755.1 hypothetical protein -
I6I43_RS03795 751126..751578 + 453 WP_000406191.1 nucleoside triphosphate pyrophosphohydrolase family protein -
I6I43_RS03800 751594..751938 + 345 WP_000817289.1 HNH endonuclease -
I6I43_RS03805 752067..752534 + 468 WP_000919026.1 phage terminase small subunit P27 family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - hlb / sea / sak / scn 731127..778491 47364


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9361.22 Da        Isoelectric Point: 3.8464

>T186687 WP_025174939.1 NZ_CP068143:748159-748410 [Staphylococcus aureus]
MNNREQIEQSIISASAYNGNDTEGLLKEVEDVYKKAQAFDEILDGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T186687 NZ_CP089742:c2433685-2432783 [Melaminivora jejuensis]
ATGAGCGCGAATCTTTCGGCATCCATCCTGGCCCGGTTGCTGACGCTTGCCAAACAACGGGATGACGACTACAGCCTGCT
GCTCAACCGCTTCGGCATGGAGCGCCTGCTGGCGCGCGTCAGCAGCTCACCGTATGCAGAGCGTTTCTTGCTCAAGGGTG
CGCTGCTCTTTGCGCTGTGGTACGACACTCCGCACCGCCCGACACGGGATGCCGACCTGCTGGGCTTCGGCCCTGATGAT
GAGACAAACCTGATAGCCACTTTCCGCGAAGTCGCTGCCATGGACCTGGACGATGGCATCGTGTTTGACCCGGAATCCGT
GAAAGCCGATGCCATTCGCGAAGACAACACCTACGGCGGCACCCGCATCACGCTGGTGGCACGCATAGGCTCTGCGCGCT
GCGCCCTGCAAATCGACGTGGGCTTTGGCGATGCCGTGACGCCAGGGCCGCAGACTGTGACTTATCCCACTTTGCTGGAC
GACTTCCAAGCCCCTACGCTGCGGGTGTATCCGGTCTACACCGTGATTGCCGAGAAGTACCAGGCCATGGTGATGCTGGG
GCAGGCAAACAGCCGCATGAAAGACTTTTTCGACCTTACGGTGATTGCAAGGCGAACAGAGCTGGACGGCGCCACGCTGG
CCACAGCCATAACCGCCACCTTTGCCCGACGCCAGACAGCATTGCCTACAGGGCGCCCGCTTGCACTGACGAAACAGTTC
AGCGAAGACCCTGCCAAGCTGCGCCAGTGGCAGGCTTTCTTGAACAAGAACCGCATTGCCGCAGCCAGTTTGGGTGACAC
CATTGCGCTGCTTGACGACCTGCTGTGGCCTCCCACGCAGGTGGCTGCCGCACACAGCCAGGCGAAGGCCACTTGGCGCC
CGGATTCCTTGCGCTGGGTTTGA

Antitoxin


Download         Length: 58 a.a.        Molecular weight: 6468.29 Da        Isoelectric Point: 4.2484

>AT186687 WP_000028424.1 NZ_CP068143:748400-748573 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDDSVISIIDFITKPIYLIKGDE

Download         Length: 174 bp

>AT186687 NZ_CP089742:c2434281-2433682 [Melaminivora jejuensis]
ATGAACCAATCCGACTACATCCTTGAACTGGCCCGGCACCGGCGCGTGCTGCGGGCGGCGGATGTGCGTGCGCAAGGCTG
GTCGCCGCAGCTTTTGATTCGGCTGCACCAGGCGGGCAAGCTGCACCGGCTGGGGCGCGGTTTGTACGGGCTGCCCGACG
CCGAAGTGACCGAGCACCAGACGCTGATCGAGGTGTGCCAGCGCGTGCCCAAGGCCGTGCTGTGCCTGCTGAGCGCGTTG
CAGTTCCACGAGATCGGCACGCAACTGCCCCACGAAGTATGGGTCGCGCTGCCTGAAGGCACGCAGGCCCCGGCGCCGGG
CTACCCGGCGCTGCGCATCACGCGCCTGCGTGGCGCCGCGTACAGCGACGGCATCCAGACAGTGGCCGAGCACGGCGCCC
CAATCCGCGTGTACAGCGCCGCCAAAACGGTGACGGACTGCTTCAAGTTCCGCAACAAGATTGGCCTGGACGTGGCGCTG
GAGGCGCTGAAAGATGCATGGCGCAGCCGAAAGGTCACCATGGACGAGCTGGGCCACTTCGCCAAGATCAATCGCGTCGA
ACGTGTCATGCAGCCTTACCTGGAGGCGGTCACGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References