Detailed information of TA system TA186681

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): sprG-sprF/-
• Location: 599370..599632
• Replicon: chromosome
• Accession: NZ_CP068143
• Organism: Staphylococcus aureus strain FDAARGOS_1086

Toxin (Protein)

• Gene name: SprG3
• Uniprot ID: Q2FWA7
• Locus tag: I6I43_RS02935
• Protein ID: WP_001802298.1
• Coordinates: 599370..599474 (+)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	SprF4
Locus tag	-
Coordinates	599469..599632 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I43_RS02920	596167..596949	+	783	WP_045177727.1	ABC transporter ATP-binding protein	-
I6I43_RS02925	597016..597873	+	858	WP_045177730.1	Cof-type HAD-IIB family hydrolase	-
I6I43_RS02930	598532..598690	-	159	WP_001792784.1	hypothetical protein	-
I6I43_RS02935	599370..599474	+	105	WP_001802298.1	hypothetical protein	Toxin
-	599469..599632	-	164	-	-	Antitoxin
I6I43_RS02940	599973..601064	-	1092	WP_045177732.1	lytic regulatory protein	-
I6I43_RS02945	601330..602310	-	981	WP_000019744.1	CDF family zinc efflux transporter CzrB	-
I6I43_RS02950	602312..602632	-	321	WP_000003759.1	Zn(II)-responsive metalloregulatory transcriptional repressor CzrA	-
I6I43_RS02955	602784..603449	+	666	WP_045177733.1	SDR family oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3906.77 Da
• Isoelectric Point: 5.5724

>T186681 WP_001802298.1 NZ_CP068143:599370-599474 [Staphylococcus aureus]
MLLLERTSMSDFEMLMVVLTIIGLVLISTQDHKK

Nucleotide

• Length: 105 bp

>T186681 NZ_CP089611:c3691795-3691367 [Mycobacterium tuberculosis]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGGGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin

Nucleotide

• Length: 164 bp

>AT186681 NZ_CP068143:c599632-599469 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Structures

Toxin

• AlphaFold DB: A0A2I7Y9L9

Antitoxin