Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 343258..343775 Replicon chromosome
Accession NZ_CP068143
Organism Staphylococcus aureus strain FDAARGOS_1086

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag I6I43_RS01605 Protein ID WP_000113262.1
Coordinates 343509..343775 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag I6I43_RS01600 Protein ID WP_000584499.1
Coordinates 343258..343509 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I43_RS01570 338956..339675 + 720 WP_000479576.1 amino acid ABC transporter permease -
I6I43_RS01575 339672..340403 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
I6I43_RS01580 340500..341750 - 1251 WP_001012241.1 FemA/FemB family glycyltransferase FmhA -
I6I43_RS01585 342005..342367 + 363 WP_000819843.1 DUF4467 domain-containing protein -
I6I43_RS01590 342386..342985 + 600 WP_000162812.1 DsbA family protein -
I6I43_RS01595 342992..343093 + 102 WP_001791744.1 hypothetical protein -
I6I43_RS01600 343258..343509 + 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I6I43_RS01605 343509..343775 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
I6I43_RS01610 344069..345619 + 1551 WP_045177665.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
I6I43_RS01615 345805..346272 + 468 WP_000153346.1 SRPBCC domain-containing protein -
I6I43_RS01620 346356..346538 + 183 WP_000230294.1 hypothetical protein -
I6I43_RS01625 346755..347579 + 825 WP_045177662.1 formate/nitrite transporter family protein -
I6I43_RS01630 347812..348348 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T186680 WP_000113262.1 NZ_CP068143:343509-343775 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T186680 NZ_CP068143:343509-343775 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT186680 WP_000584499.1 NZ_CP068143:343258-343509 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp

>AT186680 NZ_CP068143:343258-343509 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7BWF
PDB 6L8E
AlphaFold DB T1YB60

References