Detailed information of TA system TA186678

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 318250..318434
• Replicon: chromosome
• Accession: NZ_CP068143
• Organism: Staphylococcus aureus strain FDAARGOS_1086

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: I6I43_RS01470
• Protein ID: WP_000482647.1
• Coordinates: 318250..318357 (+)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	318374..318434 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I43_RS01445	313612..314085	+	474	WP_000456489.1	GyrI-like domain-containing protein	-
I6I43_RS01450	314208..315419	-	1212	WP_001192075.1	multidrug effflux MFS transporter	-
I6I43_RS01455	315601..316260	-	660	WP_000831298.1	membrane protein	-
I6I43_RS01460	316320..317462	-	1143	WP_001176863.1	glycerate kinase	-
I6I43_RS01465	317730..318116	+	387	WP_000779360.1	flippase GtxA	-
I6I43_RS01470	318250..318357	+	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	318374..318434	-	61	-	-	Antitoxin
I6I43_RS01475	319064..320827	+	1764	WP_006191000.1	ABC transporter ATP-binding protein/permease	-
I6I43_RS01480	320852..322585	+	1734	WP_000486494.1	ABC transporter ATP-binding protein/permease	-
I6I43_RS01485	322816..322983	+	168	WP_001790576.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T186678 WP_000482647.1 NZ_CP068143:318250-318357 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T186678 NZ_CP089611:3163597-3163860 [Mycobacterium tuberculosis]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT186678 NZ_CP068143:c318434-318374 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin