Detailed information of TA system TA186677

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 286711..287234
• Replicon: chromosome
• Accession: NZ_CP068143
• Organism: Staphylococcus aureus strain FDAARGOS_1086

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: I6I43_RS01330
• Protein ID: WP_045177693.1
• Coordinates: 286968..287234 (+)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: T1YBB2
• Locus tag: I6I43_RS01325
• Protein ID: WP_000587618.1
• Coordinates: 286711..286968 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I43_RS01310	283207..283956	-	750	WP_000072443.1	hypothetical protein	-
I6I43_RS01315	284151..285728	+	1578	WP_000143503.1	FMN-binding glutamate synthase family protein	-
I6I43_RS01320	285896..286351	-	456	WP_000732090.1	YehR family lipoprotein	-
I6I43_RS01325	286711..286968	+	258	WP_000587618.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
I6I43_RS01330	286968..287234	+	267	WP_045177693.1	Txe/YoeB family addiction module toxin	Toxin
I6I43_RS01335	287590..288666	+	1077	WP_001076673.1	M42 family metallopeptidase	-
I6I43_RS01340	288914..289576	+	663	WP_045177691.1	ATP-binding cassette domain-containing protein	-
I6I43_RS01345	289569..290345	+	777	WP_000072151.1	iron export ABC transporter permease subunit FetB	-
I6I43_RS01350	290741..291928	+	1188	WP_045177690.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (26-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10684.35 Da
• Isoelectric Point: 10.1384

>T186677 WP_045177693.1 NZ_CP068143:286968-287234 [Staphylococcus aureus]
MSNYTVKIKNSAKLDLKKIKHPYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Nucleotide

• Length: 267 bp

>T186677 NZ_CP089611:c3122789-3122397 [Mycobacterium tuberculosis]
ATGACGACGGTGCTGCTCGACTCGCATGTGGCCTACTGGTGGTCGGCCGAGCCGCAGCGTCTCAGCATGGCGGCGAGCCA
GGCCATCGAACACGCCGACGAGCTCGCCGTCGCCGCGATTTCGTGGTTCGAGCTGGCTTGGCTTGCCGAACAGGAACGCA
TCCAACTGGCGATTCCGGTGCTGTCCTGGCTTCAGCAGCTGGCCGAGCACGTTCGCACCGTCGGTATCACGCCCTCGGTC
GCCGCCACGGCGGTGGCGCTGCCCTCGTCGTTCCCCGGCGATCCGGCCGACCGGTTGATCTACGCCACCGCGATCGAACA
CGGCTGGCGGCTGGTGACCAAGGACCGGCGGCTACGCAGTCATCGGCACCCACGACCGGTCACCGTCTGGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9762.78 Da
• Isoelectric Point: 4.1958

>AT186677 WP_000587618.1 NZ_CP068143:286711-286968 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETMYLVSTGTMDKVREREKDNSGTTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT186677 NZ_CP089611:c3123001-3122786 [Mycobacterium tuberculosis]
ATGACCGCTACGGAGGTGAAGGCGAAGATCCTCTCCTTGCTTGATGAAGTGGCCCAGGGCGAGGAGATCGAGATCACCAA
ACACGGCCGCACCGTGGCCCGGCTGGTGGCAGCGACGGGGCCGCACGCGCTGAAGGGTCGATTCTCGGGTGTGGCGATGG
CGGCCGTGGATGACGACGAACTCTTCACCACCGGGGTTTCGTGGAACGTTTCATGA

Structures

Antitoxin

• AlphaFold DB: T1YBB2