Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 47251..47770 Replicon plasmid unnamed3
Accession NZ_CP068117
Organism Enterococcus hirae strain FDAARGOS_1125

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag I6I82_RS01195 Protein ID WP_135982204.1
Coordinates 47492..47770 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID -
Locus tag I6I82_RS01190 Protein ID WP_135982202.1
Coordinates 47251..47505 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6I82_RS01175 45046..45444 + 399 WP_135982196.1 hypothetical protein -
I6I82_RS01180 45654..46061 + 408 WP_135982198.1 hypothetical protein -
I6I82_RS01185 46341..47009 + 669 WP_135982200.1 hypothetical protein -
I6I82_RS01190 47251..47505 + 255 WP_135982202.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6I82_RS01195 47492..47770 + 279 WP_135982204.1 type II toxin-antitoxin system YafQ family toxin Toxin
I6I82_RS01200 48779..49306 + 528 WP_168353756.1 PrsW family intramembrane metalloprotease -
I6I82_RS01205 49874..50098 + 225 WP_135982245.1 hypothetical protein -
I6I82_RS01210 50115..50459 + 345 WP_135982207.1 hypothetical protein -
I6I82_RS01215 50896..51996 + 1101 WP_135982209.1 Abi family protein -
I6I82_RS01220 52082..52701 - 620 Protein_53 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..80453 80453


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(2-81)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 11180.14 Da        Isoelectric Point: 10.3493

>T186648 WP_135982204.1 NZ_CP068117:47492-47770 [Enterococcus hirae]
MLTIEFTPSFKRDYKRMMKKHYDETEFRKVINLLVKQEQEVLRTKYKDHALQGNWKGFRELHVQSDWLLIYKIDGKKLIL
TLVRTGSHDKIL

Download         Length: 279 bp

>T186648 NZ_CP089611:1389598-1390029 [Mycobacterium tuberculosis]
GTGATCATCCCTGACATCAATCTGCTGCTCTACGCGGTCATCACCGGATTCCCGCAGCACCGGCGCGCGCATGCGTGGTG
GCAAGACACCGTCAACGGCCACACCCGTATCGGGCTGACGTATCCGGCGTTGTTCGGGTTCCTACGGATCGCCACCAGTG
CCCGCGTGCTCGCCGCGCCACTGCCAACCGCGGATGCGATCGCCTATGTGCGCGAGTGGCTTTCGCAGCCGAACGTGGAC
CTACTCACGGCGGGTCCGCGCCACCTGGACATCGCGTTGGGCCTGCTCGACAAGCTCGGCACAGCCAGCCACCTAACCAC
CGATGTGCAACTGGCCGCCTACGGCATCGAATACGACGCCGAGATCCATTCCAGTGACACCGACTTTGCCCGATTCGCCG
ATCTGAAGTGGACCGACCCGTTGCGCGAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9697.93 Da        Isoelectric Point: 4.2805

>AT186648 WP_135982202.1 NZ_CP068117:47251-47505 [Enterococcus hirae]
MSRLNIRIDDELKEQAREVYEEIGMDLSTAVIVFLKQSVRERKLPFQPGNEPREDIIARYEAENGITTKVSSVDELMEKL
NADD

Download         Length: 255 bp

>AT186648 NZ_CP089611:1389341-1389601 [Mycobacterium tuberculosis]
ATGCGCACCACCTTGACGCTCGATGACGACGTCGTCCGGCTGGTCGAAGACGCAGTGCATCGCGAACGCCGCCCGATGAA
GCAGGTCATCAACGATGCGCTGCGCAGAGCGCTGGCGCCGCCGGTGAAACGGCAGGAGCAGTATCGGTTGGAGCCGCATG
AGTCGGCTGTGCGTTCCGGGTTGGATCTGGCCGGCTTCAACAAGTTGGCCGACGAACTGGAGGATGAGGCGCTGCTGGAT
GCCACGCGTCGGGCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References