Detailed information of TA system TA186641

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 36048..36640
• Replicon: plasmid unnamed2
• Accession: NZ_CP068110
• Organism: Moraxella osloensis strain FDAARGOS_1130

Toxin (Protein)

• Gene name: graT
• Uniprot ID: -
• Locus tag: I6I87_RS11075
• Protein ID: WP_201666656.1
• Coordinates: 36359..36640 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: I6I87_RS11070
• Protein ID: WP_201666655.1
• Coordinates: 36048..36344 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6I87_RS11055	33129..34511	+	1383	WP_201666653.1	replication initiation protein	-
I6I87_RS11060	34590..35351	+	762	WP_201666654.1	ParA family protein	-
I6I87_RS11065	35348..35683	+	336	WP_065262414.1	hypothetical protein	-
I6I87_RS11070	36048..36344	-	297	WP_201666655.1	HigA family addiction module antidote protein	Antitoxin
I6I87_RS11075	36359..36640	-	282	WP_201666656.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6I87_RS11080	37031..37888	+	858	WP_201666658.1	hypothetical protein	-
I6I87_RS11085	37971..38537	-	567	WP_201666660.1	recombinase family protein	-
I6I87_RS11090	39125..40324	+	1200	WP_201666591.1	ATP-binding protein	-
I6I87_RS11095	40421..41557	+	1137	WP_201666592.1	Fic family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..76702	76702

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-92)

Antitoxin

• Toxin-antitoxin system, antidote protein, HigA (5-83)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10840.31 Da
• Isoelectric Point: 6.4745

>T186641 WP_201666656.1 NZ_CP068110:c36640-36359 [Moraxella osloensis]
MIVNFACDKTQTLFITGNTRHFSSIKKVAERKLLQLDNAITLEDLRSAPGNHLETLFGDREGQHSIRINDQWRICFIWTQ
EGPIEVEIVDYHR

Nucleotide

• Length: 282 bp

>T186641 NZ_CP089611:c760610-760173 [Mycobacterium tuberculosis]
ATGATAGTGCTCGACACCACCGTCCTCGTCTATGCCAAAGGCGCCGAGCATCCACTCCGCGATCCCTGCCGCGATCTCGT
CGCGGCAATCGCCGACGAACGCATCGCTGCGACCACCACCGCCGAGGTGATCCAGGAGTTCGTCCACGTACGCGCCCGCC
GGCGCGACCGCAGCGACGCCGCCGCGCTGGGCCGTGTGACTATGCCGAACTGCTCTCGCCGCTACTCACCATCAATCGAG
GCCACCTCGAAGCGCGGCCTGACGCTGTTCGAGACAACGCCAGGGCTTGAAGCCTGCGACGCGGTGCTCGCGGCGGTTGC
CGCAAGCGCCGGCGCGACCGCTCTTGTCTCGGCTGACCCGGCGTTCGCCGATCTGTCGGATGTCGTGCACGTCATTCCCG
ACGCGGCCGGGATGGTCAGCCTGCTCGGCGACCGCTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11049.70 Da
• Isoelectric Point: 5.7011

>AT186641 WP_201666655.1 NZ_CP068110:c36344-36048 [Moraxella osloensis]
MKNSMRPIHPGEILREDYLAPLEMSANALAKAIGVTPARINEIVREERGVTADTALRLAKYFGGNAKFWLNLQTTYELRL
AETQDTHFLDEIMPLAYG

Nucleotide

• Length: 297 bp

>AT186641 NZ_CP089611:c760063-759818 [Mycobacterium tuberculosis]
ATGCTCAGCTTCCGCGCCGACGACCACGACGTCGACCTGGCCGACGCGTGGGCGCGTCGCCTACACATCGGCCGCTCCGA
GCTGCTGCGCGATGCGCTGCGACGTCACTTGGCCGCGCTGGCCGCGGACCAGGATGTCCAGGCCTACACCGAGCGACCGT
TGACGGACGACGAGAACGCACTGGCTGAGATCGCCGACTGGGGGCCGGCGGAGGACTGGGCCGACTGGGCCGATGCGGCG
CGGTGA