Detailed information of TA system TA186599

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 890539..891049
• Replicon: chromosome
• Accession: NZ_CP068079
• Organism: Staphylococcus carnosus strain FDAARGOS_1147

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: I6J04_RS04490
• Protein ID: WP_169929359.1
• Coordinates: 890539..890793 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: B9DKQ3
• Locus tag: I6J04_RS04495
• Protein ID: WP_012664283.1
• Coordinates: 890801..891049 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J04_RS04470	885584..886486	-	903	WP_046100210.1	ABC transporter substrate-binding protein	-
I6J04_RS04475	886618..888282	-	1665	WP_012664287.1	arginine--tRNA ligase	-
I6J04_RS04480	888284..888700	-	417	WP_046100211.1	DUF1934 family protein	-
I6J04_RS04485	888861..890051	-	1191	WP_046100212.1	amidohydrolase	-
I6J04_RS04490	890539..890793	-	255	WP_169929359.1	Txe/YoeB family addiction module toxin	Toxin
I6J04_RS04495	890801..891049	-	249	WP_012664283.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
I6J04_RS04500	891389..892800	-	1412	Protein_893	PLP-dependent aminotransferase family protein	-
I6J04_RS04505	892974..893343	+	370	Protein_894	fatty acid desaturase	-
I6J04_RS04510	893550..894167	+	618	WP_046100215.1	LysE family transporter	-
I6J04_RS04515	894351..894863	-	513	WP_012664280.1	YwhD family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (3-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9914.30 Da
• Isoelectric Point: 9.8956

>T186599 WP_169929359.1 NZ_CP068079:c890793-890539 [Staphylococcus carnosus]
ISFSPEVFEDYKNWQTQDKKVWKKINQLIKSIDRDGMLDGIGKPERLKGGFSGWYSRRITQDHRLVYKVTSESILAASCK
YHYQ

Nucleotide

• Length: 255 bp

>T186599 NZ_CP089610:c2208724-2208428 [Mycobacterium tuberculosis]
GTGAGTAGCCGATACCTTCTCTCGCCTGCCGCGCAGGCACATCTGGAAGAGATCTGGGACTGCACCTATGACCGTTGGGG
TGTCGATCAGGCCGAGCAGTACCTGCGCGAACTTCAACACGCTATCGACCGTGCTGCGGCAAACCCGCGGATCGGACGAG
CGTGCGACGAGATTCGCCCCGGCTATCGCAAGCTCTCGGCCGGGTCACACACGTTGTTCTATCGGGTGACTGGCGAAGGC
ACCATCGACGTCGTGCGAGTCCTGCACCAACGGATGGACGTCGACCGGAACCTCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9305.30 Da
• Isoelectric Point: 4.2081

>AT186599 WP_012664283.1 NZ_CP068079:c891049-890801 [Staphylococcus carnosus]
MAVETYSNARKNFRSLIKQVNENSEAITITTNEENAVLMSETDYNAIMETLYLQQNPANAAHLKRSIEQLEKGDSVQVEI
DE

Nucleotide

• Length: 249 bp

>AT186599 NZ_CP089610:c2208972-2208721 [Mycobacterium tuberculosis]
GTGGGTAAGAACACGTCCTTCGTCCTCGACGAGCACTACAGCGCCTTCATCGACGGCGAGATCGCCGCGGGCCGCTACCG
GTCGGCCAGTGAAGTCATCCGCTCCGCGTTGCGACTGCTCGAGGACCGTGAAACCCAGCTGCGCGCGCTTCGTGAGGCTC
TCGAGGCCGGCGAACGCAGCGGCAGCTCGACACCGTTCGACTTCGACGGATTCCTCGGTCGTAAGCGGGCTGACGCCTCG
CGTGGCCGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A380F8S2