Detailed information of TA system TA186590

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): holin-SprF1/-
• Location: 824323..824693
• Replicon: chromosome
• Accession: NZ_CP068069
• Organism: Staphylococcus equorum strain FDAARGOS_1149

Toxin (Protein)

• Gene name: holin
• Uniprot ID: A0A1E5TGW5
• Locus tag: I6J06_RS04100
• Protein ID: WP_021338679.1
• Coordinates: 824472..824693 (+)
• Length: 74 a.a.

Antitoxin (RNA)

Gene name	SprF1
Locus tag	-
Coordinates	824323..824421 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J06_RS04075	820635..821456	+	822	WP_002507957.1	succinate dehydrogenase iron-sulfur subunit	-
I6J06_RS04080	821732..822526	+	795	WP_002507956.1	glutamate racemase	-
I6J06_RS04085	822544..823125	+	582	WP_069812512.1	XTP/dITP diphosphatase	-
I6J06_RS04090	823125..823634	+	510	WP_002507954.1	metallophosphoesterase	-
-	824323..824421	-	99	-	-	Antitoxin
I6J06_RS04100	824472..824693	+	222	WP_021338679.1	phage holin	Toxin
I6J06_RS04105	824848..824964	+	117	WP_165349553.1	putative holin-like toxin	-
I6J06_RS04110	825263..825370	+	108	WP_021338681.1	putative holin-like toxin	-
I6J06_RS04115	825805..826512	+	708	WP_081329724.1	hypothetical protein	-
I6J06_RS04120	826819..828702	+	1884	WP_069812506.1	glycosyltransferase family 2 protein	-
I6J06_RS04125	828764..829321	-	558	WP_021338684.1	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Holin (7-59)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8279.78 Da
• Isoelectric Point: 4.8018

>T186590 WP_021338679.1 NZ_CP068069:824472-824693 [Staphylococcus equorum]
MDVKVTVIVRVLSLILVLVNQWLSNKEVSPIPVDESTLMTIAVALITMWKDNPFTDAAKGSFFKSYTYQLEIF

Nucleotide

• Length: 222 bp

>T186590 NZ_CP089610:c1393837-1393544 [Mycobacterium tuberculosis]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin

Nucleotide

• Length: 99 bp

>AT186590 NZ_CP068069:c824421-824323 [Staphylococcus equorum]
ATTTGATAATATTTATATGTTGTGTTAATTTATATATAGAAAAAGGGCAACACACCATACGTGTATCGCCCCAATGAGCC
CGTTAAAAAGACGGTGGCT

Structures

Toxin

• AlphaFold DB: A0A1E5TGW5

Antitoxin