Detailed information of TA system TA186580

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 2172263..2172776
• Replicon: chromosome
• Accession: NZ_CP068060
• Organism: Streptococcus anginosus strain FDAARGOS_1155

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: I0SIM6
• Locus tag: I6J12_RS10570
• Protein ID: WP_003034719.1
• Coordinates: 2172263..2172517 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: I0SIL5
• Locus tag: I6J12_RS10575
• Protein ID: WP_003034688.1
• Coordinates: 2172510..2172776 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6J12_RS10535	2168142..2168558	-	417	WP_020999431.1	conjugal transfer protein	-
I6J12_RS10540	2168560..2168787	-	228	WP_002271001.1	hypothetical protein	-
I6J12_RS10545	2168804..2169796	-	993	WP_003034679.1	conjugal transfer protein	-
I6J12_RS10550	2169806..2170360	-	555	WP_003034624.1	hypothetical protein	-
I6J12_RS10555	2170357..2170593	-	237	WP_000456039.1	hypothetical protein	-
I6J12_RS10560	2170613..2170999	-	387	WP_003034694.1	hypothetical protein	-
I6J12_RS10565	2170977..2172209	-	1233	WP_025272020.1	replication initiation factor domain-containing protein	-
I6J12_RS10570	2172263..2172517	-	255	WP_003034719.1	Txe/YoeB family addiction module toxin	Toxin
I6J12_RS10575	2172510..2172776	-	267	WP_003034688.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
I6J12_RS10580	2173040..2174698	-	1659	WP_003034653.1	cell division protein FtsK	-
I6J12_RS10585	2174705..2175115	-	411	WP_003034661.1	DUF961 family protein	-
I6J12_RS10590	2175138..2175452	-	315	WP_000406626.1	hypothetical protein	-
I6J12_RS10595	2175567..2175794	-	228	WP_003034721.1	hypothetical protein	-
I6J12_RS10600	2175791..2176027	-	237	WP_003034655.1	hypothetical protein	-
I6J12_RS10605	2176156..2176434	-	279	WP_003034637.1	type II toxin-antitoxin system YafQ family toxin	-
I6J12_RS10610	2176435..2176707	-	273	WP_003034600.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
I6J12_RS10615	2177380..2177742	+	363	WP_003034723.1	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2160908..2183206	22298

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (4-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10509.97 Da
• Isoelectric Point: 9.2761

>T186580 WP_003034719.1 NZ_CP068060:c2172517-2172263 [Streptococcus anginosus]
MFNFTEQAWKDYVSWQQEDKKILKRINRLMEDIKRNPFEGIGKPEPLKYRYSGAWSRRITDEHRLVYMVEENEIYFLSFR
DHYK

Nucleotide

• Length: 255 bp

>T186580 NZ_CP068060:c2172517-2172263 [Streptococcus anginosus]
ATGTTTAACTTTACAGAACAAGCTTGGAAAGATTATGTTTCTTGGCAACAAGAAGATAAAAAGATACTCAAACGTATCAA
TCGTTTAATGGAGGATATCAAACGAAATCCTTTTGAAGGGATTGGAAAGCCTGAACCCTTAAAATACCGTTATTCCGGTG
CTTGGTCTCGTAGAATTACAGATGAACACCGATTAGTCTATATGGTGGAAGAAAATGAGATTTATTTCTTATCCTTTCGA
GACCACTATAAATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10405.92 Da
• Isoelectric Point: 4.6437

>AT186580 WP_003034688.1 NZ_CP068060:c2172776-2172510 [Streptococcus anginosus]
MEAVVYSNFRNNLKNYMKKVNDEYEPLMVVNKNPDENIVVLSKENWDSIQETIRLMNNDYLSDKVLSGMEQVKQKKVIQR
PLLEVEDV

Nucleotide

• Length: 267 bp

>AT186580 NZ_CP068060:c2172776-2172510 [Streptococcus anginosus]
ATGGAAGCTGTCGTCTATTCAAATTTTAGAAACAATTTAAAGAATTACATGAAAAAAGTCAACGATGAATATGAACCTCT
AATGGTTGTCAATAAAAATCCTGATGAAAATATTGTGGTCTTATCTAAGGAAAACTGGGATAGTATTCAAGAAACCATTC
GCCTAATGAATAATGATTATCTTTCAGACAAGGTTCTATCAGGAATGGAACAAGTCAAGCAAAAGAAAGTCATTCAACGC
CCATTATTAGAGGTGGAAGATGTTTAA

Structures

Toxin

• AlphaFold DB: I0SIM6

Antitoxin

• AlphaFold DB: I0SIL5