Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1403958..1404578 Replicon chromosome
Accession NZ_CP068050
Organism Burkholderia gladioli strain BBB-01

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JKG63_RS24530 Protein ID WP_201447167.1
Coordinates 1403958..1404236 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A560VTG3
Locus tag JKG63_RS24535 Protein ID WP_029951048.1
Coordinates 1404255..1404578 (+) Length 108 a.a.

Genomic Context

JKG63_RS24505JKG63_RS24510JKG63_RS24515JKG63_RS24520JKG63_RS24530JKG63_RS24535JKG63_RS24540JKG63_RS24550JKG63_RS24555JKG63_RS24525JKG63_RS24545
Location: 1399051..1399653 (603 bp)
Type: Others
Protein ID: WP_013690210.1
Location: 1399846..1400946 (1101 bp)
Type: Others
Protein ID: WP_201447166.1
Location: 1401095..1401817 (723 bp)
Type: Others
Protein ID: WP_013690208.1
Location: 1402057..1402926 (870 bp)
Type: Others
Protein ID: WP_103693188.1
Location: 1403958..1404236 (279 bp)
Type: Toxin
Protein ID: WP_201447167.1
Location: 1404255..1404578 (324 bp)
Type: Antitoxin
Protein ID: WP_029951048.1
Location: 1404686..1405771 (1086 bp)
Type: Others
Protein ID: WP_036056417.1
Location: 1407164..1408342 (1179 bp)
Type: Others
Protein ID: WP_098152253.1
Location: 1408450..1408863 (414 bp)
Type: Others
Protein ID: WP_103693194.1
Location: 1403047..1403715 (669 bp)
Type: Others
Protein ID: WP_025100406.1
Location: 1405814..1406770 (957 bp)
Type: Others
Protein ID: WP_186044783.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JKG63_RS245051399051..1399653+603WP_013690210.1TetR/AcrR family transcriptional regulator-
JKG63_RS245101399846..1400946+1101WP_201447166.1helix-turn-helix transcriptional regulator-
JKG63_RS245151401095..1401817+723WP_013690208.1fumarylacetoacetate hydrolase family protein-
JKG63_RS245201402057..1402926+870WP_103693188.1CPBP family intramembrane metalloprotease-
JKG63_RS245251403047..1403715-669WP_025100406.1NAAT family transporter-
JKG63_RS245301403958..1404236+279WP_201447167.1type II toxin-antitoxin system RelE/ParE family toxinToxin
JKG63_RS245351404255..1404578+324WP_029951048.1HigA family addiction module antidote proteinAntitoxin
JKG63_RS245401404686..1405771+1086WP_036056417.1ionic transporter y4hA-
JKG63_RS245451405814..1406770-957WP_186044783.1LysR family transcriptional regulator-
JKG63_RS245501407164..1408342+1179WP_098152253.1HPP family protein-
JKG63_RS245551408450..1408863+414WP_103693194.1MarR family winged helix-turn-helix transcriptional regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(13-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10413.02 Da        Isoelectric Point: 9.9309

>T186566 WP_201447167.1 NZ_CP068050:1403958-1404236 [Burkholderia gladioli]
MIQSFRCKRTAALFAGESPPAWRAVVQVARRKLAMPDAAQALRDLAVPPGNQLEGLFGDRAGQYSIRINERWRLCFVWSS
RGPELVEIVDYH

Download         Length: 279 bp

>T186566 NZ_CP089607:c228999-228700 [Rhodococcus qingshengii]
ATGCGACCAATTCACGAAGCCGACCTCGACACAGTCCGCCCGGTCCTCGTACTCACCCGAGAGGTGGTCCGTCCACACCT
CGGGACCGTCACGGTAGCGCCCATCACCGACGAGATCCGAGGACTGTCCACTGAGGTGTCCGTCAGTGCCGCGAACGGAC
TATCTGCCGACGCGGTGGTCAGTTGCGATCACATCACCACCATTCCCGTCAGTGCGCTCGGCAACGTCATCGGTTATCTT
CTGCCAGCACAAGAAGAGTCACTGTCCATAGCCGTGCGCGCCGCATTCGATCTCGAATGA

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11903.72 Da        Isoelectric Point: 7.2024

>AT186566 WP_029951048.1 NZ_CP068050:1404255-1404578 [Burkholderia gladioli]
MNAKSVKPVNAMPAIHPGEILREEFLVPLALSVNALSLALMVPATRMHEIVNERRGITADTAYRLSRYFGTTPEFWLALQ
ADYDIKTLPNRDEIDRKVDARPNGAAA

Download         Length: 324 bp

>AT186566 NZ_CP089607:c229235-228999 [Rhodococcus qingshengii]
ATGAGCACGCAGATCGCGGTACGACTACCGGACGAGATCGTGGCATTTCTCGACGACGAAATCAGGGAACATCGCGCCAC
CTCGCGGGCCTCGGTAGTGTTGCGCGCTCTCGAACGCGAGCGTCGCCGTCAGATTGCCGCACGTGACGCGGAGATTCTCG
CGAACGCCACATCCGAACATGACCTGAGTTCTCTCGCTCACCACGCCGCCAATCCGCAGTCAACAGGCTTGAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A560VTG3

References