Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3979634..3980327 Replicon chromosome
Accession NZ_CP068041
Organism Escherichia coli strain XJW9B277

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag JJE78_RS19240 Protein ID WP_000415584.1
Coordinates 3980031..3980327 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag JJE78_RS19235 Protein ID WP_000650107.1
Coordinates 3979634..3980029 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJE78_RS19225 (3975498) 3975498..3977756 - 2259 WP_001281841.1 DNA topoisomerase IV subunit A -
JJE78_RS19230 (3977894) 3977894..3979501 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
JJE78_RS19235 (3979634) 3979634..3980029 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
JJE78_RS19240 (3980031) 3980031..3980327 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
JJE78_RS19245 (3980532) 3980532..3981014 - 483 WP_000183505.1 GyrI-like domain-containing protein -
JJE78_RS19250 (3981067) 3981067..3981459 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
JJE78_RS19255 (3981611) 3981611..3982270 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
JJE78_RS19260 (3982267) 3982267..3983616 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
JJE78_RS19265 (3983662) 3983662..3983995 - 334 Protein_3813 DUF2645 family protein -
JJE78_RS19270 (3984314) 3984314..3984895 + 582 WP_033553897.1 NADPH:quinone oxidoreductase MdaB -
JJE78_RS19275 (3984926) 3984926..3985240 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T186544 WP_000415584.1 NZ_CP068041:c3980327-3980031 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T186544 NZ_CP089592:2278196-2278312 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT186544 WP_000650107.1 NZ_CP068041:c3980029-3979634 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT186544 NZ_CP089592:c2278486-2278307 [Bacillus subtilis]
AATGATACAATTATATAATTATTTTTTGCATTTTGTTTAATTAAATGCATAAAATAAAAAGACCAGGGTGTTGGTAGCAC
CCTGGCTCTGTACAAAAGCTGCCCATCAAAGGGCTTGCTCGTTGTCAAATCTGCGTAGGCCTAACCCTTCAGGTGTCCAA
ACTCAAGGGAAGGTCTATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References