Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3947277..3948004 Replicon chromosome
Accession NZ_CP068035
Organism Escherichia coli strain U90

Toxin (Protein)


Gene name higB Uniprot ID J7Q991
Locus tag JKF55_RS19090 Protein ID WP_000547564.1
Coordinates 3947693..3948004 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JKF55_RS19085 Protein ID WP_000126294.1
Coordinates 3947277..3947696 (-) Length 140 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JKF55_RS19065 3942327..3942854 - 528 WP_001078777.1 electron transport protein HydN -
JKF55_RS19070 3943003..3944013 - 1011 WP_063102913.1 DNA-binding transcriptional regulator AscG -
JKF55_RS19075 3944273..3945730 + 1458 WP_001107856.1 PTS cellobiose/arbutin/salicin transporter subunit IIBC -
JKF55_RS19080 3945739..3947163 + 1425 WP_063102937.1 6-phospho-beta-glucosidase AscB -
JKF55_RS19085 3947277..3947696 - 420 WP_000126294.1 helix-turn-helix domain-containing protein Antitoxin
JKF55_RS19090 3947693..3948004 - 312 WP_000547564.1 type II toxin-antitoxin system HigB family toxin Toxin
JKF55_RS19095 3948178..3948939 - 762 WP_001026446.1 hypothetical protein -
JKF55_RS19100 3948964..3949434 - 471 WP_000132961.1 hydrogenase maturation peptidase HycI -
JKF55_RS19105 3949427..3949837 - 411 WP_001291921.1 formate hydrogenlyase assembly protein HycH -
JKF55_RS19110 3949834..3950601 - 768 WP_000067399.1 formate hydrogenlyase subunit HycG -
JKF55_RS19115 3950601..3951143 - 543 WP_000493792.1 formate hydrogenlyase subunit HycF -
JKF55_RS19120 3951153..3952862 - 1710 WP_001288134.1 formate hydrogenlyase subunit HycE -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12426.13 Da        Isoelectric Point: 9.7248

>T186510 WP_000547564.1 NZ_CP068035:c3948004-3947693 [Escherichia coli]
MHIISKAPFEESARKYPNDALALQALYRVIKETDFSTPEEMRTAFPNLDNFRYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

>T186510 NZ_CP089532:c208879-208304 [Pseudomonas veronii]
ATGAGGCATTCACCTTTCACAGCCTTCTACGACGCGAATGTTCTCTACCCTGCACCACTGCGTGACTACTTGATGCATCT
AGCCTTGACCGGCGTGTACCGCGCACGCTGGTCAGCTCTGATTCATGAAGAATGGAAGCGCAATCTACTGATCAACCGTC
CAGAGCTTACACGTGAGCAATTGGACCGAACGTCCTCGCTGATGGATAAAGCCGTTCCGGATGGTATTGTCACTGAATAC
GAGCCTCTTATAGAGGGACTGACTCTACCGGACGCTGACGACCGCCATGTGCTGGCAGCAGCTATCAAATGTAACGCCTC
GGTTATCGTGACTTTTAACCTTAAGGATTTCCCAAAGAGCGCTCTCGACGCGTTCGATATAGAGCCATTACACCCTGACG
ACTTTATTGCCGACCTATGGGATCTAGATCAAGCAGCTGTTTTGGAAGCAGCGCAAAGGCAGCGTGCATCCCTGAAAAAC
CCACCGCATAGCGCACGCGAGTATCTAGATAAGCTACTACAGCAGAAGCTACCCGAAACCGTAAAATTGCTGTCCGGTTT
TGAGTTCCTGATTTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15416.42 Da        Isoelectric Point: 4.4596

>AT186510 WP_000126294.1 NZ_CP068035:c3947696-3947277 [Escherichia coli]
MTANAARAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLASRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp

>AT186510 NZ_CP089532:c209343-208876 [Pseudomonas veronii]
ATGACCACCGCCAACCTCGCTCGCACCATTCTTCCCGATGAGAAGGAAATCGCTGCGGCCGTGGCGTCAAGCCGTCAGTT
GGCCGCCTTCCTCACAACAAAATTTGAGACACAACGCATTGAGTTGGTTGACGAAACGCAACACCGCGAAGTCGTCGAAC
TTCCTACTTTCGCCCTCCGTTTACTCGGCGAAATTTTAAGCGAACTCGCGCTGGGTAACGCCGTCAAGGTCGTGCCGATT
CATGCGGAATTAACGACCCAAGAAGGGGCAGACATGCTCAATGTTTCGCGGCCTCACCTGGTGAAACTACTGGATAACGG
CGCATTGCCCCACACCAAAACCGGGAGACATCGTAGGATCAAGTTCGCTGATCTAATGACCTACAAGGAGCAGCGCGACC
TGGCAAGCCGTAATGCCATGGATGAGCTAGCTGCACAAGCCCAAGAATTAGGGATGGGGTATGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0A0FJG5


Antitoxin

Source ID Structure

References