Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2066754..2067259 Replicon chromosome
Accession NZ_CP068012
Organism Actinomyces sp. HMT 175

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag JJJ14_RS08775 Protein ID WP_081093133.1
Coordinates 2066754..2067020 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1F1VSH2
Locus tag JJJ14_RS08780 Protein ID WP_029316340.1
Coordinates 2067017..2067259 (-) Length 81 a.a.

Genomic Context

JJJ14_RS08755JJJ14_RS08760JJJ14_RS08765JJJ14_RS08795JJJ14_RS08770JJJ14_RS08775JJJ14_RS08780JJJ14_RS08790
Location: 2063960..2064175 (216 bp)
Type: Others
Protein ID: WP_009407243.1
Location: 2064333..2064929 (597 bp)
Type: Others
Protein ID: WP_201443892.1
Location: 2064998..2065752 (755 bp)
Type: Others
Protein ID: Protein_1703
Location: 2071014..2071595 (582 bp)
Type: Others
Protein ID: WP_201445143.1
Location: 2065749..2066588 (840 bp)
Type: Others
Protein ID: WP_101558783.1
Location: 2066754..2067020 (267 bp)
Type: Toxin
Protein ID: WP_081093133.1
Location: 2067017..2067259 (243 bp)
Type: Antitoxin
Protein ID: WP_029316340.1
Location: 2067573..2070779 (3207 bp)
Type: Others
Protein ID: WP_201443893.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
JJJ14_RS087552063960..2064175+216WP_009407243.1DUF3107 domain-containing protein-
JJJ14_RS087602064333..2064929+597WP_201443892.1sugar O-acetyltransferase-
JJJ14_RS087652064998..2065752+755Protein_1703NAD-dependent protein deacylase-
JJJ14_RS087702065749..2066588-840WP_101558783.1polyphosphate kinase 2-
JJJ14_RS087752066754..2067020-267WP_081093133.1Txe/YoeB family addiction module toxinToxin
JJJ14_RS087802067017..2067259-243WP_029316340.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
JJJ14_RS087902067573..2070779-3207WP_201443893.1UPF0182 family protein-
JJJ14_RS087952071014..2071595+582WP_201445143.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(26-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-67)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10436.16 Da        Isoelectric Point: 10.5624

>T186415 WP_081093133.1 NZ_CP068012:c2067020-2066754 [Actinomyces sp. HMT 175]
VSSWRIVFSRQAQKDAKKLAAAGLKPKTEKLLNLMRENPFVKPPRYEKLVGDLSGCYSRRITIQHRLVYEVHTDERTIHV
LRMWTHYE

Download         Length: 267 bp

>T186415 NZ_CP089428:44781-45065 [Klebsiella pneumoniae]
ATGACCTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTCCATGGACGCAAAGACCAGTACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTAACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACAATTTGACCAAACACAGAAATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8975.97 Da        Isoelectric Point: 4.0078

>AT186415 WP_029316340.1 NZ_CP068012:c2067259-2067017 [Actinomyces sp. HMT 175]
VSTIPVTTARSQLYRLIDQVNEDSEPLVITGQRGNAVLVGEEDWRAIQETLYLESVPGMMDSIRNARREGIEAGSEELDW

Download         Length: 243 bp

>AT186415 NZ_CP089428:44543-44791 [Klebsiella pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACCTTCAATGCAGG
AGAAGGTGCCCCGGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGCTGGGTCATATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1F1VSH2

References