Detailed information of TA system TA186408

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symER/SymE(toxin)
• Location: 3960593..3961005
• Replicon: chromosome
• Accession: NZ_CP067994
• Organism: Escherichia coli strain CV601

Toxin (Protein)

• Gene name: symE
• Uniprot ID: U9YSY7
• Locus tag: JJT18_RS19280
• Protein ID: WP_000132601.1
• Coordinates: 3960664..3961005 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	symR
Locus tag	-
Coordinates	3960593..3960669 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JJT18_RS19270	3957456..3959045	+	1590	WP_001063204.1	type I restriction-modification system methyltransferase	-
JJT18_RS19275	3959042..3960436	+	1395	WP_001272447.1	type I restriction-modification system specificity subunit	-
-	3960593..3960669	-	77	NuclAT_14	-	Antitoxin
-	3960593..3960669	-	77	NuclAT_14	-	Antitoxin
-	3960593..3960669	-	77	NuclAT_14	-	Antitoxin
-	3960593..3960669	-	77	NuclAT_14	-	Antitoxin
-	3960593..3960669	-	77	NuclAT_15	-	Antitoxin
-	3960593..3960669	-	77	NuclAT_15	-	Antitoxin
-	3960593..3960669	-	77	NuclAT_15	-	Antitoxin
-	3960593..3960669	-	77	NuclAT_15	-	Antitoxin
JJT18_RS19280	3960664..3961005	+	342	WP_000132601.1	endoribonuclease SymE	Toxin
JJT18_RS19285	3961167..3962546	+	1380	WP_000443951.1	5-methylcytosine-specific restriction endonuclease subunit McrB	-
JJT18_RS19290	3962546..3963592	+	1047	WP_000437621.1	5-methylcytosine-specific restriction endonuclease system specificity protein McrC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12203.02 Da
• Isoelectric Point: 8.5012

>T186408 WP_000132601.1 NZ_CP067994:3960664-3961005 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Nucleotide

• Length: 342 bp

>T186408 NZ_CP089427:1943878-1943980 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 77 bp

>AT186408 NZ_CP067994:c3960669-3960593 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Toxin

• AlphaFold DB: U9YSY7

Antitoxin