Detailed information of TA system TA186379

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1626170..1626682
• Replicon: chromosome
• Accession: NZ_CP067992
• Organism: Streptococcus mitis strain S022-V7-A3

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: JJN14_RS08090
• Protein ID: WP_201058376.1
• Coordinates: 1626170..1626424 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: JJN14_RS08095
• Protein ID: WP_201058377.1
• Coordinates: 1626428..1626682 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JJN14_RS08070	1622258..1622572	-	315	WP_000979235.1	DNA-directed RNA polymerase subunit omega	-
JJN14_RS08075	1622597..1623223	-	627	WP_000775041.1	guanylate kinase	-
JJN14_RS08080	1623468..1624295	+	828	WP_201058374.1	DUF4839 domain-containing protein	-
JJN14_RS08085	1624366..1625979	-	1614	WP_201058375.1	ribonuclease Y	-
JJN14_RS08090	1626170..1626424	-	255	WP_201058376.1	Txe/YoeB family addiction module toxin	Toxin
JJN14_RS08095	1626428..1626682	-	255	WP_201058377.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
JJN14_RS08100	1626814..1627911	-	1098	WP_201058378.1	nucleotidyltransferase	-
JJN14_RS08105	1627934..1629709	-	1776	WP_201058379.1	AAA family ATPase	-
JJN14_RS08110	1629742..1630488	-	747	WP_201059154.1	class I SAM-dependent methyltransferase	-
JJN14_RS08115	1630593..1630946	-	354	WP_201058380.1	ribosome silencing factor	-
JJN14_RS08120	1630947..1631540	-	594	WP_201058381.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10101.57 Da
• Isoelectric Point: 8.8069

>T186379 WP_201058376.1 NZ_CP067992:c1626424-1626170 [Streptococcus mitis]
MLLKFTEDAWADYCYWQTQDKKTLKRINKIIKDIQRNPFTGIGKPEPLKYDYQGAWSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Nucleotide

• Length: 255 bp

>T186379 NZ_CP089403:c5151606-5151503 [Klebsiella pasteurii]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9720.02 Da
• Isoelectric Point: 4.8430

>AT186379 WP_201058377.1 NZ_CP067992:c1626682-1626428 [Streptococcus mitis]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQIH
VIEE

Nucleotide

• Length: 255 bp

>AT186379 NZ_CP089403:5151496-5151664 [Klebsiella pasteurii]
AATAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCCTTATAAGAATAGTTTACCGTGTCAGGTTTTCCAGTCCGTGACAAAAGTG
GACGAATAA