Detailed information of TA system TA186364

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1800892..1801552
• Replicon: chromosome
• Accession: NZ_CP067966
• Organism: Klebsiella quasipneumoniae strain ARLG-8054

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: JJ669_RS08790
• Protein ID: WP_072413417.1
• Coordinates: 1801199..1801552 (-)
• Length: 118 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: JJ669_RS08785
• Protein ID: WP_072413418.1
• Coordinates: 1800892..1801194 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JJ669_RS08760 (1796098)	1796098..1797201	-	1104	WP_130953023.1	AarF/UbiB family protein	-
JJ669_RS08770 (1797724)	1797724..1799160	+	1437	WP_032456343.1	EmmdR/YeeO family multidrug/toxin efflux MATE transporter	-
JJ669_RS08780 (1799524)	1799524..1800456	+	933	Protein_1715	integrase arm-type DNA-binding domain-containing protein	-
JJ669_RS08785 (1800892)	1800892..1801194	-	303	WP_072413418.1	XRE family transcriptional regulator	Antitoxin
JJ669_RS08790 (1801199)	1801199..1801552	-	354	WP_072413417.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
JJ669_RS08795 (1802050)	1802050..1802271	-	222	WP_047738806.1	helix-turn-helix transcriptional regulator	-
JJ669_RS08800 (1802268)	1802268..1802729	-	462	WP_049004530.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-81)

Sequences

Toxin

Protein

• Length: 118 a.a.
• Molecular weight: 13500.41 Da
• Isoelectric Point: 9.5699

>T186364 WP_072413417.1 NZ_CP067966:c1801552-1801199 [Klebsiella quasipneumoniae]
MWTIKTTDTFDRWFASLSDTDRVSMLAALLVLREKGPGLSRPYADTVRGSRYSNMKELRIQSRGDPIRAFFAFDPTRTGI
VLCAGNKVGNEKRFYDEMLPVADREFTNWLNTLKEKE

Nucleotide

• Length: 354 bp

>T186364 NZ_CP089385:c5469248-5468865 [Klebsiella variicola subsp. variicola]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGTACGCGAATGGCGCTAAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTGATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAACTACACCCTGAATAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 10998.71 Da
• Isoelectric Point: 5.7316

>AT186364 WP_072413418.1 NZ_CP067966:c1801194-1800892 [Klebsiella quasipneumoniae]
VGRTLEQLIADEKSEVVAEAQAMATDILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFVL

Nucleotide

• Length: 303 bp

>AT186364 NZ_CP089385:c5469490-5469248 [Klebsiella variicola subsp. variicola]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA