Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2593240..2593828 Replicon chromosome
Accession NZ_CP067420
Organism Skermanella sp. TT6

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IGS68_RS12205 Protein ID WP_201080326.1
Coordinates 2593240..2593518 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IGS68_RS12210 Protein ID WP_201080328.1
Coordinates 2593541..2593828 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGS68_RS12180 2588730..2589305 - 576 WP_201080318.1 protein-tyrosine-phosphatase -
IGS68_RS12185 2589444..2590547 + 1104 WP_201080320.1 alpha/beta fold hydrolase -
IGS68_RS12190 2590612..2590788 + 177 WP_201081744.1 hypothetical protein -
IGS68_RS12195 2590903..2592294 + 1392 WP_201080322.1 dipeptidase -
IGS68_RS12200 2592301..2593089 - 789 WP_201080324.1 3'-5' exonuclease -
IGS68_RS12205 2593240..2593518 + 279 WP_201080326.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IGS68_RS12210 2593541..2593828 + 288 WP_201080328.1 HigA family addiction module antidote protein Antitoxin
IGS68_RS12215 2593973..2594467 + 495 WP_201080330.1 GAF domain-containing protein -
IGS68_RS12220 2594533..2596065 + 1533 WP_201080332.1 altronate dehydratase family protein -
IGS68_RS12225 2596103..2596954 + 852 WP_201080333.1 fumarylacetoacetate hydrolase family protein -
IGS68_RS12230 2596967..2597557 - 591 WP_201080335.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-91)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-80)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10616.06 Da        Isoelectric Point: 9.0454

>T186325 WP_201080326.1 NZ_CP067420:2593240-2593518 [Skermanella sp. TT6]
MIKSFRDKTTEELFRLGSARRFSSISKVALRKLDMINAAIALDDLRSPPGNRLEALKGDRYGQHSIRINEQWRICFRWSG
DGADDVEIVDYQ

Download         Length: 279 bp

>T186325 NZ_CP089325:1882012-1882114 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10602.10 Da        Isoelectric Point: 8.6592

>AT186325 WP_201080328.1 NZ_CP067420:2593541-2593828 [Skermanella sp. TT6]
MRLKTHPGEVLREEFLAPLGLSANALATALRVPVTRISEIIHERRAVTADTALRLGRYFGTSPEFWMNLQQAYDLSVAAR
DRGGDIERDVQPRAA

Download         Length: 288 bp

>AT186325 NZ_CP089325:c1882121-1881976 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References