Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 922452..922882 Replicon chromosome
Accession NZ_CP067420
Organism Skermanella sp. TT6

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IGS68_RS04315 Protein ID WP_201077605.1
Coordinates 922452..922574 (+) Length 41 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IGS68_RS04320 Protein ID WP_201077606.1
Coordinates 922589..922882 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IGS68_RS04285 917488..918258 - 771 WP_201077595.1 peptidoglycan editing factor PgeF -
IGS68_RS04290 918308..919414 - 1107 WP_201081072.1 SAM-dependent methyltransferase -
IGS68_RS04295 919398..920246 - 849 WP_201077597.1 prolipoprotein diacylglyceryl transferase -
IGS68_RS04300 920467..920841 + 375 WP_201077599.1 accessory factor UbiK family protein -
IGS68_RS04305 921107..921613 + 507 WP_201077601.1 YbjN domain-containing protein -
IGS68_RS04310 921617..922432 + 816 WP_201077603.1 pyrroline-5-carboxylate reductase -
IGS68_RS04315 922452..922574 + 123 WP_201077605.1 hypothetical protein Toxin
IGS68_RS04320 922589..922882 + 294 WP_201077606.1 HigA family addiction module antidote protein Antitoxin
IGS68_RS04325 922947..923810 - 864 WP_201077608.1 RNA polymerase factor sigma-32 -
IGS68_RS04330 924009..924635 + 627 WP_201077610.1 TetR/AcrR family transcriptional regulator -
IGS68_RS04335 924752..925204 + 453 WP_201077612.1 phasin family protein -
IGS68_RS04340 925329..925694 + 366 WP_201077614.1 tRNA-binding protein -
IGS68_RS04345 925836..926978 + 1143 WP_201077616.1 cache and HAMP domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-90)


Sequences

Toxin        


Download         Length: 41 a.a.        Molecular weight: 4733.14 Da        Isoelectric Point: 4.2309

>T186323 WP_201077605.1 NZ_CP067420:922452-922574 [Skermanella sp. TT6]
MEALSADRLGQHSIRIDDQRRVCFEWRDGDAYDVEIVDDH

Download         Length: 123 bp

>T186323 NZ_CP089325:759395-759880 [Klebsiella pneumoniae]
ATGATCTTGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTAGTTAAT
GCCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10208.46 Da        Isoelectric Point: 4.1829

>AT186323 WP_201077606.1 NZ_CP067420:922589-922882 [Skermanella sp. TT6]
MADFPSAHPGDVLGEDFLKPLGMSGSAPAPAIDVPESLAGDLLDGRCGVTPDTALRLARYFGTSAEFWLGMQTTYDLESA
RDAVGAEIEARVRPRAA

Download         Length: 294 bp

>AT186323 NZ_CP089325:759105-759398 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References