Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1062186..1062836 Replicon chromosome
Accession NZ_CP067413
Organism Raoultella ornithinolytica strain TET32

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JJL43_RS05085 Protein ID WP_088402264.1
Coordinates 1062495..1062836 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JJL43_RS05080 Protein ID WP_088402265.1
Coordinates 1062186..1062485 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJL43_RS05070 1058599..1059333 + 735 WP_004866964.1 phosphoadenosine phosphosulfate reductase -
JJL43_RS05075 1059388..1062093 - 2706 WP_201165805.1 CRISPR-associated helicase Cas3' -
JJL43_RS05080 1062186..1062485 - 300 WP_088402265.1 helix-turn-helix transcriptional regulator Antitoxin
JJL43_RS05085 1062495..1062836 - 342 WP_088402264.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JJL43_RS05090 1063196..1064731 + 1536 WP_201165806.1 type I-E CRISPR-associated protein Cse1/CasA -
JJL43_RS05095 1064748..1065350 + 603 WP_201165478.1 type I-E CRISPR-associated protein Cse2/CasB -
JJL43_RS05100 1065373..1066428 + 1056 WP_201165484.1 type I-E CRISPR-associated protein Cas7/Cse4/CasC -
JJL43_RS05105 1066438..1067163 + 726 WP_201165807.1 type I-E CRISPR-associated protein Cas5/CasD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-88)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12985.68 Da        Isoelectric Point: 5.1498

>T186303 WP_088402264.1 NZ_CP067413:c1062836-1062495 [Raoultella ornithinolytica]
MWDIETTDAFDEWFAAQTGTLQEDMLAAMVILSEYGPQLGRPFADTVNDSAFPNMKELRVQHQGNPIRAFFAFDPSRHGI
VLCAGDKTGLNEKKFYRDMLRLADNEYRKHLNK

Download         Length: 342 bp

>T186303 NZ_CP089316:389146-389433 [Citrobacter portucalensis]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11048.85 Da        Isoelectric Point: 8.6005

>AT186303 WP_088402265.1 NZ_CP067413:c1062485-1062186 [Raoultella ornithinolytica]
MATLKELMAKQSPESRERIAEKVEELRQTIALNMLREELNISQTELAAAMGVKQPTVAKMEQADNDPRLSTLKRYVTALG
GELSIDVKLPTGKRVAFHL

Download         Length: 300 bp

>AT186303 NZ_CP089316:388907-389146 [Citrobacter portucalensis]
ATGGGTAGCATTAACCTACGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGACTTTGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References