Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 5636650..5637254 Replicon chromosome
Accession NZ_CP067412
Organism Pseudomonas sp. HS6

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag JJN09_RS25620 Protein ID WP_249484289.1
Coordinates 5636650..5636970 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag JJN09_RS25625 Protein ID WP_127796615.1
Coordinates 5636967..5637254 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJN09_RS25600 (JJN09_25565) 5633572..5634075 - 504 WP_249484285.1 polysaccharide deacetylase -
JJN09_RS25605 (JJN09_25570) 5634380..5634661 + 282 WP_249484286.1 hypothetical protein -
JJN09_RS25610 (JJN09_25575) 5634764..5635891 + 1128 WP_249484287.1 hypothetical protein -
JJN09_RS25615 (JJN09_25580) 5636239..5636538 + 300 WP_249484288.1 hypothetical protein -
JJN09_RS25620 (JJN09_25585) 5636650..5636970 + 321 WP_249484289.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JJN09_RS25625 (JJN09_25590) 5636967..5637254 + 288 WP_127796615.1 NadS family protein Antitoxin
JJN09_RS25630 (JJN09_25595) 5637320..5638861 - 1542 WP_249484290.1 phosphoenolpyruvate carboxykinase -
JJN09_RS25635 (JJN09_25600) 5639043..5639945 - 903 WP_249484291.1 Hsp33 family molecular chaperone HslO -
JJN09_RS25640 (JJN09_25605) 5640050..5640850 + 801 WP_249484292.1 phosphatase PAP2 family protein -
JJN09_RS25645 (JJN09_25610) 5640918..5641325 - 408 WP_249484293.1 S4 domain-containing protein -
JJN09_RS25650 (JJN09_25615) 5641442..5642221 + 780 WP_249484294.1 EAL domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-101)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-86)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12056.04 Da        Isoelectric Point: 10.3556

>T186300 WP_249484289.1 NZ_CP067412:5636650-5636970 [Pseudomonas sp. HS6]
MIFVETRIFTRRVKELLDDHTYAAFQKQLVVSPSIGDVIEGTGGIRKTRIAAKGHGKRGGARVIYYHFVSASQIGLLMIY
PKNEQHDLSSDERKALKVLIEKWRCP

Download         Length: 321 bp

>T186300 NZ_CP089315:c4882637-4882380 [Klebsiella michiganensis]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACATCCGCGATGCATC
AGGCCGCGTCACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCTTACCGCATCAATACCACCGGGCTGAATAACGTCCGCGCA
CAGCTGGACAATCGCTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10746.33 Da        Isoelectric Point: 7.4052

>AT186300 WP_127796615.1 NZ_CP067412:5636967-5637254 [Pseudomonas sp. HS6]
MSKFFDELMESVQEMDEIVRGQRAPSREFHVDALQVKEIRKATGLTQTKFAALIDVQLGTLRNWEQGRREPTGPAKALLK
AIHNDPVHVLNALAH

Download         Length: 288 bp

>AT186300 NZ_CP089315:c4882369-4881818 [Klebsiella michiganensis]
ATGACAAACCACAGCTTCACTTTTCATGTCGCCTCTGAAGGCGATACCGATGACATTCTCGACGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCGATTTGCTCAACGATGAGAGCGCCTGCCCGACGCTATCGCTGCTGGCCA
GGCATAACGGAGAGGCGGTTGGGCATATTTTATTCACCCGGGCGACGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTGGCGGTGGTGCCGGAATACCAGGGCGCGGGCGTTGGCGGAGAGCTTATCCGGCACGGCATTGAGCA
GTTGAAAGCAATGGGAAGCCAGGCGGTATTTGTTCTGGGCCACGCCGCTTACTACCCCAGGCACGGGTTTGAGCCAGGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCGATTCCCGCGGCGCATAAAGCCTGCTGGATGCTGCAGCCGATTTCGTCT
CAGCCGCTGGGACGAACGGGCCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References