Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 35971..36698 | Replicon | plasmid pXJW9B263-1 |
| Accession | NZ_CP067400 | ||
| Organism | Escherichia coli strain XJW9B263 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A663AUB1 |
| Locus tag | JJF91_RS23520 | Protein ID | WP_000558568.1 |
| Coordinates | 35971..36282 (+) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | V0AHC4 |
| Locus tag | JJF91_RS23525 | Protein ID | WP_000990392.1 |
| Coordinates | 36279..36698 (+) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JJF91_RS23480 (JJF91_23370) | 31388..31639 | + | 252 | WP_216778056.1 | hypothetical protein | - |
| JJF91_RS23485 (JJF91_23375) | 32020..32358 | + | 339 | WP_152924794.1 | hypothetical protein | - |
| JJF91_RS23490 (JJF91_23380) | 32408..32746 | + | 339 | WP_044069309.1 | hypothetical protein | - |
| JJF91_RS23495 (JJF91_23385) | 32946..33650 | + | 705 | WP_009364894.1 | IS6-like element IS26 family transposase | - |
| JJF91_RS23500 | 33786..34028 | + | 243 | Protein_34 | ISNCY family transposase | - |
| JJF91_RS23505 (JJF91_23390) | 34077..34304 | + | 228 | WP_181727888.1 | helix-turn-helix domain-containing protein | - |
| JJF91_RS23510 (JJF91_23395) | 34345..35313 | - | 969 | WP_000654811.1 | IS5 family transposase | - |
| JJF91_RS23515 (JJF91_23400) | 35346..35741 | + | 396 | Protein_37 | Tn3 family transposase | - |
| JJF91_RS23520 (JJF91_23405) | 35971..36282 | + | 312 | WP_000558568.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| JJF91_RS23525 (JJF91_23410) | 36279..36698 | + | 420 | WP_000990392.1 | helix-turn-helix domain-containing protein | Antitoxin |
| JJF91_RS24855 | 36735..37559 | - | 825 | WP_001141174.1 | hypothetical protein | - |
| JJF91_RS23535 (JJF91_23420) | 37684..38388 | - | 705 | WP_061872725.1 | IS6-like element IS26 family transposase | - |
| JJF91_RS24860 | 38445..38576 | - | 132 | Protein_42 | arsenical pump-driving ATPase | - |
| JJF91_RS23545 (JJF91_23430) | 38696..39256 | - | 561 | WP_216778058.1 | recombinase family protein | - |
| JJF91_RS23550 (JJF91_23435) | 39304..40008 | - | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
| JJF91_RS23560 (JJF91_23445) | 40937..41536 | + | 600 | Protein_46 | Tn3 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | blaTEM-1B / aph(6)-Id / aph(3'')-Ib / sul2 / dfrA14 | - | 1..138776 | 138776 | |
| - | inside | IScluster/Tn | blaTEM-1B / aph(6)-Id / aph(3'')-Ib / sul2 / dfrA14 | - | 16289..46134 | 29845 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12372.11 Da Isoelectric Point: 10.0935
>T186289 WP_000558568.1 NZ_CP067400:35971-36282 [Escherichia coli]
MHVVSRAPFDTATRQFPNQAAALDDVYRTLKRENYTSPDEMKKRFASLDRMKYREKWWVIDVGGGNLRVMFFADFERGKI
FIKHITTHAEYDKLTDFYRRTKE
MHVVSRAPFDTATRQFPNQAAALDDVYRTLKRENYTSPDEMKKRFASLDRMKYREKWWVIDVGGGNLRVMFFADFERGKI
FIKHITTHAEYDKLTDFYRRTKE
Download Length: 312 bp
>T186289 NZ_CP089313:2449999-2450283 [Salmonella enterica subsp. enterica serovar Indiana]
ATGACTTATAAGCTGGCATTTAACGAATCTGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTACGGGAACGACTCGAAAACCCTCGGGTTCCTGCTTCGCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGGCACAGAAGCTAA
ATGACTTATAAGCTGGCATTTAACGAATCTGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTACGGGAACGACTCGAAAACCCTCGGGTTCCTGCTTCGCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGGCACAGAAGCTAA
Antitoxin
Download Length: 140 a.a. Molecular weight: 15534.71 Da Isoelectric Point: 4.4702
>AT186289 WP_000990392.1 NZ_CP067400:36279-36698 [Escherichia coli]
MMYTDAIQAANSLVSIVPLLGGNASRKDYEDALTLVEYLVEHEPDHPLVDMLVAKIAQYEDEAEEFAEFNDRIAALPSGV
ALLRVLMDQHKLTQSDFEEEIGKKSLVSRILNGTRSLTLDHMKALARRFNIPPSSFMDA
MMYTDAIQAANSLVSIVPLLGGNASRKDYEDALTLVEYLVEHEPDHPLVDMLVAKIAQYEDEAEEFAEFNDRIAALPSGV
ALLRVLMDQHKLTQSDFEEEIGKKSLVSRILNGTRSLTLDHMKALARRFNIPPSSFMDA
Download Length: 420 bp
>AT186289 NZ_CP089313:2449761-2450009 [Salmonella enterica subsp. enterica serovar Indiana]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A663AUB1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V0AHC4 |