Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/UPF0150(antitoxin) |
Location | 2489422..2490060 | Replicon | chromosome |
Accession | NZ_CP067399 | ||
Organism | Escherichia coli strain XJW9B263 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A0A0A6TXU8 |
Locus tag | JJF91_RS12260 | Protein ID | WP_001447010.1 |
Coordinates | 2489884..2490060 (-) | Length | 59 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | - |
Locus tag | JJF91_RS12255 | Protein ID | WP_001270286.1 |
Coordinates | 2489422..2489838 (-) | Length | 139 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JJF91_RS12235 (2484574) | 2484574..2485515 | - | 942 | WP_001251304.1 | ABC transporter permease | - |
JJF91_RS12240 (2485516) | 2485516..2486529 | - | 1014 | WP_000220396.1 | ABC transporter ATP-binding protein | - |
JJF91_RS12245 (2486547) | 2486547..2487692 | - | 1146 | WP_000047424.1 | ABC transporter substrate-binding protein | - |
JJF91_RS12250 (2487937) | 2487937..2489343 | - | 1407 | WP_000760626.1 | PLP-dependent aminotransferase family protein | - |
JJF91_RS12255 (2489422) | 2489422..2489838 | - | 417 | WP_001270286.1 | type II toxin-antitoxin system antitoxin HicB | Antitoxin |
JJF91_RS12260 (2489884) | 2489884..2490060 | - | 177 | WP_001447010.1 | type II toxin-antitoxin system mRNA interferase toxin HicA | Toxin |
JJF91_RS12265 (2490282) | 2490282..2490512 | + | 231 | WP_000494244.1 | YncJ family protein | - |
JJF91_RS12270 (2490604) | 2490604..2492565 | - | 1962 | WP_001303492.1 | 23S rRNA 5-hydroxycytidine C2501 synthase | - |
JJF91_RS12275 (2492638) | 2492638..2493174 | - | 537 | WP_000429155.1 | DNA-binding transcriptional regulator SutR | - |
JJF91_RS12280 (2493266) | 2493266..2494441 | + | 1176 | WP_001236265.1 | BenE family transporter YdcO | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
flank | IS/Tn | - | - | 2494481..2495629 | 1148 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 59 a.a. Molecular weight: 6779.86 Da Isoelectric Point: 11.2298
>T186283 WP_001447010.1 NZ_CP067399:c2490060-2489884 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS
Download Length: 177 bp
>T186283 NZ_CP089312:7435352-7435699 [Streptomyces sp. GQFP]
ATGAATCGCGGTGAGATCTACTTGGTGGACCTCGACCCCGCAGTGGGTAGCGAGGCGAACAAGACGCGCCCGGCGATCCT
TGTGACCAACAATGCCGCCAACCGCATGGCGGACCGCGCGGGGCGAGGTGTCCTGGCAGTCGTGCCGGTGACGTCGAACA
TCACGCATGTGCGGCCGTTCCAGGTGTTGTTGCACGCGGCCGAGTGCGGCCTGAGGGTGGACTCCAAGGCGCAGTGCGAA
CAGATTCGGGCCCTCGACTTCTCCAGGATCGGGCACCGCATCGGAACGGTGCCACCGCATGCGCTCAAGGAGATCGACCG
GGCGCTTCGGCAGCAACTGGCGCTCTGA
ATGAATCGCGGTGAGATCTACTTGGTGGACCTCGACCCCGCAGTGGGTAGCGAGGCGAACAAGACGCGCCCGGCGATCCT
TGTGACCAACAATGCCGCCAACCGCATGGCGGACCGCGCGGGGCGAGGTGTCCTGGCAGTCGTGCCGGTGACGTCGAACA
TCACGCATGTGCGGCCGTTCCAGGTGTTGTTGCACGCGGCCGAGTGCGGCCTGAGGGTGGACTCCAAGGCGCAGTGCGAA
CAGATTCGGGCCCTCGACTTCTCCAGGATCGGGCACCGCATCGGAACGGTGCCACCGCATGCGCTCAAGGAGATCGACCG
GGCGCTTCGGCAGCAACTGGCGCTCTGA
Antitoxin
Download Length: 139 a.a. Molecular weight: 15246.63 Da Isoelectric Point: 4.7386
>AT186283 WP_001270286.1 NZ_CP067399:c2489838-2489422 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV
Download Length: 417 bp
>AT186283 NZ_CP089312:7435135-7435365 [Streptomyces sp. GQFP]
ATGAAGATCAGTGTGAGTCTGCCGGAGGATGATGTCACCTTCGTCGATGAGTACGCGGCCAAGAAGGCTGCGGAATCCCG
GTCCGCCGTGATACATGCCGCCATTCAGATGCTGCGCGAGTCGGCACTCGAAGAGGAGTACCTCGCTGCATGGGACGAGT
GGTATGCGAGCGAAGACGCGGAACTGTGGGACCGCACGGTGGGGGACGGCATCTCAGATGAATCGCGGTGA
ATGAAGATCAGTGTGAGTCTGCCGGAGGATGATGTCACCTTCGTCGATGAGTACGCGGCCAAGAAGGCTGCGGAATCCCG
GTCCGCCGTGATACATGCCGCCATTCAGATGCTGCGCGAGTCGGCACTCGAAGAGGAGTACCTCGCTGCATGGGACGAGT
GGTATGCGAGCGAAGACGCGGAACTGTGGGACCGCACGGTGGGGGACGGCATCTCAGATGAATCGCGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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