Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2489422..2490060 Replicon chromosome
Accession NZ_CP067399
Organism Escherichia coli strain XJW9B263

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag JJF91_RS12260 Protein ID WP_001447010.1
Coordinates 2489884..2490060 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag JJF91_RS12255 Protein ID WP_001270286.1
Coordinates 2489422..2489838 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJF91_RS12235 (2484574) 2484574..2485515 - 942 WP_001251304.1 ABC transporter permease -
JJF91_RS12240 (2485516) 2485516..2486529 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
JJF91_RS12245 (2486547) 2486547..2487692 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
JJF91_RS12250 (2487937) 2487937..2489343 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
JJF91_RS12255 (2489422) 2489422..2489838 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
JJF91_RS12260 (2489884) 2489884..2490060 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
JJF91_RS12265 (2490282) 2490282..2490512 + 231 WP_000494244.1 YncJ family protein -
JJF91_RS12270 (2490604) 2490604..2492565 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
JJF91_RS12275 (2492638) 2492638..2493174 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
JJF91_RS12280 (2493266) 2493266..2494441 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2494481..2495629 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T186283 WP_001447010.1 NZ_CP067399:c2490060-2489884 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T186283 NZ_CP089312:7435352-7435699 [Streptomyces sp. GQFP]
ATGAATCGCGGTGAGATCTACTTGGTGGACCTCGACCCCGCAGTGGGTAGCGAGGCGAACAAGACGCGCCCGGCGATCCT
TGTGACCAACAATGCCGCCAACCGCATGGCGGACCGCGCGGGGCGAGGTGTCCTGGCAGTCGTGCCGGTGACGTCGAACA
TCACGCATGTGCGGCCGTTCCAGGTGTTGTTGCACGCGGCCGAGTGCGGCCTGAGGGTGGACTCCAAGGCGCAGTGCGAA
CAGATTCGGGCCCTCGACTTCTCCAGGATCGGGCACCGCATCGGAACGGTGCCACCGCATGCGCTCAAGGAGATCGACCG
GGCGCTTCGGCAGCAACTGGCGCTCTGA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT186283 WP_001270286.1 NZ_CP067399:c2489838-2489422 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT186283 NZ_CP089312:7435135-7435365 [Streptomyces sp. GQFP]
ATGAAGATCAGTGTGAGTCTGCCGGAGGATGATGTCACCTTCGTCGATGAGTACGCGGCCAAGAAGGCTGCGGAATCCCG
GTCCGCCGTGATACATGCCGCCATTCAGATGCTGCGCGAGTCGGCACTCGAAGAGGAGTACCTCGCTGCATGGGACGAGT
GGTATGCGAGCGAAGACGCGGAACTGTGGGACCGCACGGTGGGGGACGGCATCTCAGATGAATCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References