Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 606491..607290 Replicon chromosome
Accession NZ_CP067399
Organism Escherichia coli strain XJW9B263

Toxin (Protein)


Gene name yhaV Uniprot ID A0A0A6SPA6
Locus tag JJF91_RS02915 Protein ID WP_000347275.1
Coordinates 606491..606955 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag JJF91_RS02920 Protein ID WP_001307405.1
Coordinates 606955..607290 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJF91_RS02885 (601492) 601492..601926 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
JJF91_RS02890 (601944) 601944..602822 - 879 WP_039268471.1 PTS N-acetylgalactosamine transporter subunit IID -
JJF91_RS02895 (602812) 602812..603591 - 780 WP_000406209.1 PTS N-acetylgalactosamine transporter subunit IIC -
JJF91_RS02900 (603602) 603602..604075 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
JJF91_RS02905 (604098) 604098..605378 - 1281 WP_039268470.1 tagatose-bisphosphate aldolase subunit KbaZ -
JJF91_RS02910 (605627) 605627..606436 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
JJF91_RS02915 (606491) 606491..606955 - 465 WP_000347275.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
JJF91_RS02920 (606955) 606955..607290 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
JJF91_RS02925 (607439) 607439..609010 - 1572 WP_001273752.1 galactarate dehydratase -
JJF91_RS02930 (609385) 609385..610719 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
JJF91_RS02935 (610735) 610735..611505 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17820.29 Da        Isoelectric Point: 9.8492

>T186265 WP_000347275.1 NZ_CP067399:c606955-606491 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKVPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T186265 NZ_CP089309:c1229349-1229023 [Thiocapsa bogorovii]
ATGACACGTGGCGACCTGGTGACCATCGTCATACCCGGTGATTTCGGCAAGCCGCGGCCGGCGTTGGTGATCCAGGCCGA
TCAGTTCCATGAGCATGCCACCCGCACCGTGCTGCCGGTGACCAGCACACTGGTGGCGGCGCCGCTGTTCCGCATCACAC
TCGAGCCCAGCGGGGAAAATGGCCTAACGAAGCCATCTCAGGTCATGGTGGACAAAGCGATGACCGTTAAGCGGGACAAA
GTCGGCCCGGTGTTCGGGCGGATCGATCTCGACAAGCTGGTGGAGATCGAGCGCGCCCTGGCCGTGTTCTTGGGCATAGC
CAAATGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT186265 WP_001307405.1 NZ_CP067399:c607290-606955 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT186265 NZ_CP089309:c1229570-1229346 [Thiocapsa bogorovii]
ATGGCATCCACGCACGTCAACACACGCGTCCAAAAACACCGCGCTGCGCTGCGCAGGGCTGGGCTGCGTCCGGTGCAGAT
TTGGGTACCCGATACGCGTCGGGCAGGCTTTGCGGAGGAATGTCGGCGACAGTCTCGACTCGCCGCCCAAGCCGATGCCG
CGGACAGCGACATGCAGCAATGGATGGACGAAGCCCTGACCGACCTGGATGGCTGGTCCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6SPA6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References