Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4501336..4502117 | Replicon | chromosome |
| Accession | NZ_CP067397 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain LB5000 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | JJB81_RS21710 | Protein ID | WP_000626099.1 |
| Coordinates | 4501626..4502117 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | JJB81_RS21705 | Protein ID | WP_001110452.1 |
| Coordinates | 4501336..4501629 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JJB81_RS21670 (4496948) | 4496948..4497853 | + | 906 | WP_001268200.1 | YjiK family protein | - |
| JJB81_RS21675 (4498192) | 4498192..4498650 | + | 459 | WP_210138849.1 | IS200/IS605-like element IS200F family transposase | - |
| JJB81_RS21680 (4498859) | 4498859..4499128 | - | 270 | WP_010989096.1 | hypothetical protein | - |
| JJB81_RS21685 (4499136) | 4499136..4499351 | - | 216 | WP_001595136.1 | hypothetical protein | - |
| JJB81_RS21690 (4499374) | 4499374..4499661 | - | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| JJB81_RS21695 (4499658) | 4499658..4500533 | - | 876 | WP_000921675.1 | AraC family transcriptional regulator | - |
| JJB81_RS21700 (4500798) | 4500798..4501019 | - | 222 | WP_001576552.1 | hypothetical protein | - |
| JJB81_RS21705 (4501336) | 4501336..4501629 | + | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| JJB81_RS21710 (4501626) | 4501626..4502117 | + | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| JJB81_RS21715 (4502365) | 4502365..4503117 | - | 753 | WP_210138850.1 | phosphatase PAP2 family protein | - |
| JJB81_RS23875 (4503220) | 4503220..4503294 | - | 75 | Protein_4247 | porin family protein | - |
| JJB81_RS21720 (4504326) | 4504326..4504703 | - | 378 | WP_000916345.1 | EthD family reductase | - |
| JJB81_RS21725 (4504775) | 4504775..4505107 | + | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| JJB81_RS21730 (4505198) | 4505198..4505275 | + | 78 | Protein_4250 | helix-turn-helix domain-containing protein | - |
| JJB81_RS21740 (4505546) | 4505546..4506121 | - | 576 | WP_001188509.1 | transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| flank | IS/Tn | - | - | 4498192..4498650 | 458 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T186261 WP_000626099.1 NZ_CP067397:4501626-4502117 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T186261 NZ_CP089309:c1223131-1222877 [Thiocapsa bogorovii]
ATGCAAACCATCACCTTCTCCGATGCCCGCAATCAACTGAAGCAAGTGCTTGATCGCGTAGCAGACGACGCGGACTACAC
GGTCATCACCCGTCGAGATGCTGAAGACGCGGTCGTGATGTCCCTCGACAGCTTCAATAGTCTGATGGAGACGGTCCACC
TGCTTCGCTCACCGGCCAACGCCGAGCATCTCGCCCGCTCCATTGCCCAATACCGCCAGGGACAGACCGCCGAGCATCCG
TTGCAGCATGACTAG
ATGCAAACCATCACCTTCTCCGATGCCCGCAATCAACTGAAGCAAGTGCTTGATCGCGTAGCAGACGACGCGGACTACAC
GGTCATCACCCGTCGAGATGCTGAAGACGCGGTCGTGATGTCCCTCGACAGCTTCAATAGTCTGATGGAGACGGTCCACC
TGCTTCGCTCACCGGCCAACGCCGAGCATCTCGCCCGCTCCATTGCCCAATACCGCCAGGGACAGACCGCCGAGCATCCG
TTGCAGCATGACTAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT186261 WP_001110452.1 NZ_CP067397:4501336-4501629 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT186261 NZ_CP089309:c1222884-1222624 [Thiocapsa bogorovii]
ATGACTAGACGGCTCGCTTGGACCGAAGAGGCCTGGGCAGACCACGTCTACTGGCAAAGCCAAGACCGCAAGACCCTGAA
GCGCATCAACGCGCTCATCGCCGACGTGCTGCGGACGCCGTTCGAAGGTATCGGCAAACCCGAGGCCTTGCGGGAAAACC
TGAGCGGATTCTGGTCGCGTCGCATCGACCAAGCGAATCGCCTGGTCTACGCCGTCGATACGGAGCAGATCACCATCATT
TCCTGCCATTATCACTATTGA
ATGACTAGACGGCTCGCTTGGACCGAAGAGGCCTGGGCAGACCACGTCTACTGGCAAAGCCAAGACCGCAAGACCCTGAA
GCGCATCAACGCGCTCATCGCCGACGTGCTGCGGACGCCGTTCGAAGGTATCGGCAAACCCGAGGCCTTGCGGGAAAACC
TGAGCGGATTCTGGTCGCGTCGCATCGACCAAGCGAATCGCCTGGTCTACGCCGTCGATACGGAGCAGATCACCATCATT
TCCTGCCATTATCACTATTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 | |
| AlphaFold DB | A0A5I1DGA4 |