Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4178433..4179187 | Replicon | chromosome |
| Accession | NZ_CP067397 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain LB5000 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5F003 |
| Locus tag | JJB81_RS20270 | Protein ID | WP_000558166.1 |
| Coordinates | 4178876..4179187 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | JJB81_RS20265 | Protein ID | WP_001259011.1 |
| Coordinates | 4178433..4178879 (-) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JJB81_RS20235 (4173609) | 4173609..4174505 | + | 897 | WP_001520529.1 | sugar kinase | - |
| JJB81_RS20240 (4174539) | 4174539..4175342 | + | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| JJB81_RS20245 (4175533) | 4175533..4176132 | + | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| JJB81_RS20250 (4176126) | 4176126..4176998 | + | 873 | WP_000921427.1 | virulence factor BrkB family protein | - |
| JJB81_RS20255 (4176995) | 4176995..4177432 | + | 438 | WP_000560974.1 | D-aminoacyl-tRNA deacylase | - |
| JJB81_RS20260 (4177477) | 4177477..4178418 | + | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| JJB81_RS20265 (4178433) | 4178433..4178879 | - | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| JJB81_RS20270 (4178876) | 4178876..4179187 | - | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| JJB81_RS20275 (4179273) | 4179273..4180202 | - | 930 | WP_001127703.1 | alpha/beta hydrolase | - |
| JJB81_RS20280 (4180420) | 4180420..4180731 | + | 312 | WP_001159630.1 | cytotoxic translational repressor of toxin-antitoxin stability system | - |
| JJB81_RS20285 (4180732) | 4180732..4181022 | + | 291 | WP_000362050.1 | DNA-binding transcriptional regulator | - |
| JJB81_RS20290 (4181069) | 4181069..4181998 | - | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| JJB81_RS20295 (4181995) | 4181995..4182630 | - | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| JJB81_RS20300 (4182627) | 4182627..4183529 | - | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T186259 WP_000558166.1 NZ_CP067397:c4179187-4178876 [Salmonella enterica subsp. enterica serovar Typhimurium]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T186259 NZ_CP089309:c818420-817959 [Thiocapsa bogorovii]
ATGCGGGTCTTTCGGCTCGTCAAGGAACGATTCGCCGACAACGCCCTGGACGGTTCGGGCGCGAAGGTCTACGGCGGACG
CTGGAATCGCAAGGGTAATGCGGCCGTGTACACCTTGGACAGCATCGCGCTGGCGGCTCTCGAGCTTCTGGTGCATCTGC
ATCGCAGCGAGGTGCTGAATCGGTATTGTTTGGTGACCCTCGATCTTCCCGATGAGGATGTGCTGGTTCTGGACGACGCC
GGACTGCCCGAGGATTGGCGAGACGATCCCGCACCTGTCTCGACCGCGGCGATCGGAAGCGCCTGGTTGGCCGGCGGCCA
ATCACTCGCGCTGTCGGTTCCGAGTGTCCTGATTCCGCAGCAACGCAACTTTGTGTTGAATCCCGGTCATGCGGCGTCAG
GCGCGGTGTTCGCGACGGCAACGCTCGAATCCTTCGATCTTGATCCACGTCTTGTTCGTTGA
ATGCGGGTCTTTCGGCTCGTCAAGGAACGATTCGCCGACAACGCCCTGGACGGTTCGGGCGCGAAGGTCTACGGCGGACG
CTGGAATCGCAAGGGTAATGCGGCCGTGTACACCTTGGACAGCATCGCGCTGGCGGCTCTCGAGCTTCTGGTGCATCTGC
ATCGCAGCGAGGTGCTGAATCGGTATTGTTTGGTGACCCTCGATCTTCCCGATGAGGATGTGCTGGTTCTGGACGACGCC
GGACTGCCCGAGGATTGGCGAGACGATCCCGCACCTGTCTCGACCGCGGCGATCGGAAGCGCCTGGTTGGCCGGCGGCCA
ATCACTCGCGCTGTCGGTTCCGAGTGTCCTGATTCCGCAGCAACGCAACTTTGTGTTGAATCCCGGTCATGCGGCGTCAG
GCGCGGTGTTCGCGACGGCAACGCTCGAATCCTTCGATCTTGATCCACGTCTTGTTCGTTGA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16734.08 Da Isoelectric Point: 6.6451
>AT186259 WP_001259011.1 NZ_CP067397:c4178879-4178433 [Salmonella enterica subsp. enterica serovar Typhimurium]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT186259 NZ_CP089309:c818908-818420 [Thiocapsa bogorovii]
ATGGAGTCGCACGCGAGAGTTTTCCGGATTCCGGTGTCTTCCGGTGCCGCCGACGCCGAGATCGCTCCCGGAGGTGGGGC
GACGGTCTTTCTGCGCCTCGGACTTCCGACCGATCGGGCGGGTCTGGTCGCCGAGAGCCGCCGTGGCTTTCCGGTGACCG
TCATCGAGCGGCTGGCCGAGATCCTCGACCGGCCGCAGCAGACTCTGCTGCGAATCGCCAAGATTGCACCGTCCACTCTG
ACCCGGCGTCGGCGCAGCCCCGACGGGCGCCTGTCTCCGGAAGAGAGCGATCGTGTCTACCGCATCGCGGCTGCGTTCGG
CGATGCGGTGGATCTCTTCGAGGGCGACGCCTCCGCCGCGTCCGGGTGGCTCGGCGAGCCGGCGAAGGCGCTGGGCGGGA
CGGCGCCGATCGAGCATCTGGATACCGAGGCCGGCGCCACGCAGGTGCACGACCTCATCGGGCGTCTGGAGCATGGCGTC
TACAGCTGA
ATGGAGTCGCACGCGAGAGTTTTCCGGATTCCGGTGTCTTCCGGTGCCGCCGACGCCGAGATCGCTCCCGGAGGTGGGGC
GACGGTCTTTCTGCGCCTCGGACTTCCGACCGATCGGGCGGGTCTGGTCGCCGAGAGCCGCCGTGGCTTTCCGGTGACCG
TCATCGAGCGGCTGGCCGAGATCCTCGACCGGCCGCAGCAGACTCTGCTGCGAATCGCCAAGATTGCACCGTCCACTCTG
ACCCGGCGTCGGCGCAGCCCCGACGGGCGCCTGTCTCCGGAAGAGAGCGATCGTGTCTACCGCATCGCGGCTGCGTTCGG
CGATGCGGTGGATCTCTTCGAGGGCGACGCCTCCGCCGCGTCCGGGTGGCTCGGCGAGCCGGCGAAGGCGCTGGGCGGGA
CGGCGCCGATCGAGCATCTGGATACCGAGGCCGGCGCCACGCAGGTGCACGACCTCATCGGGCGTCTGGAGCATGGCGTC
TACAGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|