Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3618475..3619013 Replicon chromosome
Accession NZ_CP067397
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain LB5000

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag JJB81_RS17665 Protein ID WP_001526148.1
Coordinates 3618475..3618750 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag JJB81_RS17670 Protein ID WP_000729713.1
Coordinates 3618753..3619013 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB81_RS17660 (3615682) 3615682..3618387 + 2706 WP_000907029.1 HTH-type transcriptional regulator MalT -
JJB81_RS17665 (3618475) 3618475..3618750 - 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
JJB81_RS17670 (3618753) 3618753..3619013 - 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
JJB81_RS17675 (3619122) 3619122..3620141 - 1020 WP_000101027.1 RNA 3'-terminal phosphate cyclase -
JJB81_RS17680 (3620145) 3620145..3621359 - 1215 WP_001105522.1 RNA-splicing ligase RtcB -
JJB81_RS17685 (3621707) 3621707..3621898 - 192 Protein_3470 TROVE domain-containing protein -
JJB81_RS17690 (3621907) 3621907..3623460 - 1554 WP_000013008.1 TROVE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T186256 WP_001526148.1 NZ_CP067397:c3618750-3618475 [Salmonella enterica subsp. enterica serovar Typhimurium]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T186256 NZ_CP089307:c2679525-2679142 [Lacticaseibacillus paracasei]
ATGGATGTGTCCGTAAAACGCGGCGATGTTTTTTTCGCCGATCTGTCTCCGGTTGTCGGCTCCGAACAAGGCGGCAACCG
GCCAGTACTTATTATTCAAAACAACGTTGGCAACCATTACAGTCCCACAGTGATTGTGGCAGCCATTACCTCCAAGATTC
AAAAACCCAAGATGCCGACGCATGTCGGGTTACGGGCCAAGCAAGATGGCGTTGAACGCAACTCGGTCATTTTACTTGAG
CAAATTCGCACGATTGACAAGCAACGGCTACAAGCCCGCGTGACAGCTCTGTCAAGCACCAAAATGGCAGCAGTCGACCG
CGCGTTGGCGATTTCAGTGGGTCTGGTCAGTTTGCCCAAGCCCAAAACATATAATAAGAATTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT186256 WP_000729713.1 NZ_CP067397:c3619013-3618753 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT186256 NZ_CP089307:c2679793-2679545 [Lacticaseibacillus paracasei]
ATGAAAAAGCAAACGTCAGTAGCGGTAACGTTTGATGATGCCATTAAGGCGCGGTTGGATGCCTATTGTGAATTGAATGA
CATTGACGCTCAGGCTGTGATTACGGAGGCAGTGGCGACATTTTTGAAGTCACAGGCTCCCGAAATCAACCAATTGATTT
CTGGCTATGTAGCAATGGGCCAGATCAATACAGAGATCAGTCATGCTTTCTCTGCCTGCGAGAGCGAGGTATACGCCCAT
ATTCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References