Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 1990220..1990880 | Replicon | chromosome |
| Accession | NZ_CP067391 | ||
| Organism | Klebsiella grimontii strain 5512.56 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A285B6D8 |
| Locus tag | JJJ11_RS11725 | Protein ID | WP_004132737.1 |
| Coordinates | 1990220..1990573 (+) | Length | 118 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | A0A9E1DQ94 |
| Locus tag | JJJ11_RS11730 | Protein ID | WP_004132739.1 |
| Coordinates | 1990578..1990880 (+) | Length | 101 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JJJ11_RS11700 (JJJ11_11700) | 1985604..1986371 | - | 768 | WP_004132727.1 | molybdopterin-dependent oxidoreductase | - |
| JJJ11_RS11705 (JJJ11_11705) | 1986361..1986969 | - | 609 | WP_004132729.1 | cytochrome b/b6 domain-containing protein | - |
| JJJ11_RS11710 (JJJ11_11710) | 1986984..1987610 | - | 627 | WP_004132731.1 | hypothetical protein | - |
| JJJ11_RS11715 (JJJ11_11715) | 1987750..1988418 | + | 669 | WP_004132733.1 | heavy metal response regulator transcription factor | - |
| JJJ11_RS11720 (JJJ11_11720) | 1988418..1989836 | + | 1419 | WP_049085817.1 | heavy metal sensor histidine kinase | - |
| JJJ11_RS11725 (JJJ11_11725) | 1990220..1990573 | + | 354 | WP_004132737.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| JJJ11_RS11730 (JJJ11_11730) | 1990578..1990880 | + | 303 | WP_004132739.1 | XRE family transcriptional regulator | Antitoxin |
| JJJ11_RS11735 (JJJ11_11735) | 1991074..1991277 | + | 204 | Protein_1841 | hypothetical protein | - |
| JJJ11_RS11740 (JJJ11_11740) | 1991278..1991611 | + | 334 | Protein_1842 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| JJJ11_RS11745 (JJJ11_11745) | 1992067..1992930 | + | 864 | WP_016240040.1 | DUF6387 family protein | - |
| JJJ11_RS11750 (JJJ11_11750) | 1993117..1993332 | + | 216 | WP_000250489.1 | AlpA family transcriptional regulator | - |
| JJJ11_RS11755 (JJJ11_11755) | 1993362..1993673 | + | 312 | WP_001515481.1 | hypothetical protein | - |
| JJJ11_RS11760 (JJJ11_11760) | 1993688..1994074 | + | 387 | WP_016240041.1 | hypothetical protein | - |
| JJJ11_RS11765 (JJJ11_11765) | 1994091..1994378 | + | 288 | WP_016240042.1 | hypothetical protein | - |
| JJJ11_RS11770 (JJJ11_11770) | 1994469..1994762 | + | 294 | WP_209573990.1 | hypothetical protein | - |
| JJJ11_RS11775 (JJJ11_11775) | 1994875..1995270 | + | 396 | WP_045910839.1 | hypothetical protein | - |
| JJJ11_RS11780 (JJJ11_11780) | 1995367..1995660 | - | 294 | WP_065782198.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 118 a.a. Molecular weight: 13554.49 Da Isoelectric Point: 10.0045
>T186223 WP_004132737.1 NZ_CP067391:1990220-1990573 [Klebsiella grimontii]
VWMIKTTDTFERWFTSFNDTDRASVLAALLVLREKGPGLSRPNADTLRGSRYSNMKELRIQSRGEPIRAFFAFDPARTGI
VLCAGNKVGNEKRFYDEMLPVAEREFTNWLKTFKEKE
VWMIKTTDTFERWFTSFNDTDRASVLAALLVLREKGPGLSRPNADTLRGSRYSNMKELRIQSRGEPIRAFFAFDPARTGI
VLCAGNKVGNEKRFYDEMLPVAEREFTNWLKTFKEKE
Download Length: 354 bp
>T186223 NZ_CP089272:c4969557-4969207 [Escherichia coli O157:H7]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 101 a.a. Molecular weight: 11072.83 Da Isoelectric Point: 5.7424
>AT186223 WP_004132739.1 NZ_CP067391:1990578-1990880 [Klebsiella grimontii]
MGRTLEQLMADEKPEVVADARAMAADILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFEL
MGRTLEQLMADEKPEVVADARAMAADILLNIHLAELREKVQKTQVEMAQALGIRQPTVAGMEKPGRDLKLSTLKRYVEAT
GGKLRLDVELPDGSHYGFEL
Download Length: 303 bp
>AT186223 NZ_CP089272:c4969802-4969551 [Escherichia coli O157:H7]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGTGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGTGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|