186220

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 42901..43551 Replicon chromosome
Accession NZ_CP067391
Organism Klebsiella grimontii strain 5512.56

Toxin (Protein)


Gene name higB Uniprot ID A0A9E1GCI7
Locus tag JJJ11_RS02555 Protein ID WP_024360564.1
Coordinates 42901..43242 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A9E1GGB7
Locus tag JJJ11_RS02560 Protein ID WP_024360565.1
Coordinates 43252..43551 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJJ11_RS02540 (JJJ11_02540) 39134..40453 + 1320 WP_004133107.1 MFS transporter -
JJJ11_RS02545 (JJJ11_02545) 40599..41990 + 1392 WP_004126843.1 hexose-6-phosphate:phosphate antiporter -
JJJ11_RS02550 (JJJ11_02550) 42202..42654 + 453 WP_049087028.1 DUF1198 domain-containing protein -
JJJ11_RS02555 (JJJ11_02555) 42901..43242 + 342 WP_024360564.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JJJ11_RS02560 (JJJ11_02560) 43252..43551 + 300 WP_024360565.1 helix-turn-helix transcriptional regulator Antitoxin
JJJ11_RS02565 (JJJ11_02565) 43669..44850 + 1182 WP_024360566.1 purine ribonucleoside efflux pump NepI -
JJJ11_RS02570 (JJJ11_02570) 44969..46348 - 1380 WP_004133118.1 carbohydrate porin -
JJJ11_RS02575 (JJJ11_02575) 46451..46753 - 303 WP_004855598.1 PTS lactose/cellobiose transporter subunit IIA -
JJJ11_RS02580 (JJJ11_02580) 46861..48186 - 1326 WP_004133122.1 PTS sugar transporter subunit IIC -
JJJ11_RS02585 (JJJ11_02585) 48198..48509 - 312 WP_049131329.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-83)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 13091.97 Da        Isoelectric Point: 5.7558

>T186220 WP_024360564.1 NZ_CP067391:42901-43242 [Klebsiella grimontii]
MWDVETTEVFDKWFEAQIEALKEDMLAAMVILSEYGPQLGRPFADTVNDSAFSNMKELRVQHRGSPIRAFFVFDPSRRGI
VLCAGDKTGLNEKRFYKDMIKLADAEYRKHLNQ

Download         Length: 342 bp

>T186220 NZ_CP089272:c4484077-4483679 [Escherichia coli O157:H7]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAGCTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACTTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAATCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10994.92 Da        Isoelectric Point: 9.7256

>AT186220 WP_024360565.1 NZ_CP067391:43252-43551 [Klebsiella grimontii]
MATLKELMAKQSPESQARIAEKVEEMRQAIALSMLREELNMSQAELAKAMGVKQPTIAKMEQADNDPRLSTLKRYVVALG
GELSIDVKLPTGKRIAFHL

Download         Length: 300 bp

>AT186220 NZ_CP089272:c4484373-4484080 [Escherichia coli O157:H7]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAATTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References