Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3701228..3701769 Replicon chromosome
Accession NZ_CP067342
Organism Escherichia coli strain ECJXMCRH7

Toxin (Protein)


Gene name yafQ Uniprot ID A0A140NAP5
Locus tag JJB06_RS18205 Protein ID WP_000615981.1
Coordinates 3701491..3701769 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag JJB06_RS18200 Protein ID WP_000729704.1
Coordinates 3701228..3701488 (+) Length 87 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB06_RS18180 (3696911) 3696911..3697696 - 786 WP_000207564.1 putative lateral flagellar export/assembly protein LafU -
JJB06_RS18185 (3697668) 3697668..3699380 + 1713 Protein_3572 flagellar biosynthesis protein FlhA -
JJB06_RS18190 (3699596) 3699596..3700093 - 498 WP_000006260.1 REP-associated tyrosine transposase RayT -
JJB06_RS18195 (3700269) 3700269..3701042 - 774 WP_001353765.1 C40 family peptidase -
JJB06_RS18200 (3701228) 3701228..3701488 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
JJB06_RS18205 (3701491) 3701491..3701769 + 279 WP_000615981.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
JJB06_RS18210 (3701925) 3701925..3702665 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
JJB06_RS18215 (3702636) 3702636..3703403 - 768 WP_000333379.1 class II glutamine amidotransferase -
JJB06_RS18220 (3703609) 3703609..3704187 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fdeC / fdeC / ykgK/ecpR / yagZ/ecpA / yagY/ecpB / yagX/ecpC / yagW/ecpD / yagV/ecpE / gmhA/lpcA / tssA / hcp1/tssD1 3647873..3721534 73661


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10860.65 Da        Isoelectric Point: 10.0702

>T186147 WP_000615981.1 NZ_CP067342:3701491-3701769 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQSSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T186147 NZ_CP089227:c6927900-6927532 [Nocardia asteroides]
GTGACCTGGGAGATTGTCCTGCATCCGGAGGTGGAGTCATGGTTCTTGGCAATCTGCGGCACGGACCCCGAGACGGGTGA
CCTGATCGAGCGGGCAATCGATCACCTCGCATCGGAAGGACCGAGCCTGGGCCGACCGCTGGTCGACCGCATCAAAGGCA
GCCGATATCACAATATGAAGGAGTTACGGCCGGCCTCGACCGGCACGACCGAGGTCCGGATACTGTTCGCCTTCGACCCC
GCCCGTGCCGCTGCGATGCTGGTGGCCGGGGACAAATCCAATTTCTGGCAGGGTTGGTACAGCGAGGCGATACCGCTGGC
CGACAAACGCTTCACCGAGCACCTGGAAGCGTTGAAGGAGCAGTCATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT186147 WP_000729704.1 NZ_CP067342:3701228-3701488 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT186147 NZ_CP089227:c6927535-6927203 [Nocardia asteroides]
ATGAGCACCGAATTCAGCAAGTGGACCGACGTCAAAGCCAGGGCCCGGCAGCAGGATCCGAGGTCGGAAGCGGAGCAGAC
GGCAGGCGCGCTTCGCGCGGACGAGCGCCACGAGTCGTACCTGCGCGGACATCAGCTCGCGGAAATTCGCAAAGCCATGG
GAATGACCCAGGTGGCGCTCGCCGAAGCCCTCGGAGTCACACAGGCACGGGTGTCGAAGATCGAGCGAGGCGAGATCTCG
GGGATAGACGCGATTCGGGCGTATGTGACCGCACTCGGCGGATCGGTCGATGTGGTCGTGCGGCTTGGCGATCGGACCTG
GAACGTAGCCTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4MMG
PDB 4MMJ
PDB 4ML2
PDB 4ML0


Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References