Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1921580..1922082 Replicon chromosome
Accession NZ_CP067342
Organism Escherichia coli strain ECJXMCRH7

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag JJB06_RS09350 Protein ID WP_000767829.1
Coordinates 1921828..1922082 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag JJB06_RS09345 Protein ID WP_219360902.1
Coordinates 1921580..1921831 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJB06_RS09315 (1916663) 1916663..1917730 - 1068 WP_113403919.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
JJB06_RS09320 (1917730) 1917730..1918800 - 1071 WP_000108985.1 histidinol-phosphate transaminase -
JJB06_RS09325 (1918797) 1918797..1920101 - 1305 WP_001300981.1 histidinol dehydrogenase -
JJB06_RS09330 (1920107) 1920107..1920412 - 306 Protein_1830 ATP phosphoribosyltransferase -
JJB06_RS09335 (1920785) 1920785..1921101 - 317 Protein_1831 ATP phosphoribosyltransferase -
JJB06_RS09340 (1921247) 1921247..1921297 - 51 WP_001364200.1 his operon leader peptide -
JJB06_RS09345 (1921580) 1921580..1921831 + 252 WP_219360902.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
JJB06_RS09350 (1921828) 1921828..1922082 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
JJB06_RS09355 (1922165) 1922165..1922989 + 825 WP_000754737.1 SDR family oxidoreductase -
JJB06_RS09360 (1923035) 1923035..1923964 + 930 WP_000803374.1 LysR substrate-binding domain-containing protein -
JJB06_RS09365 (1924179) 1924179..1924241 + 63 WP_010723108.1 membrane protein YoeI -
JJB06_RS09370 (1924231) 1924231..1925589 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T186132 WP_000767829.1 NZ_CP067342:1921828-1922082 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T186132 NZ_CP089224:3422036-3422467 [Mycobacterium ostraviense]
ATGCTTTGCGTTGACGTCAACGTTCTCGTCTATGCACATCGCGCGGACCTCCGTGAACATTCGAGCTATCGGAGTTTGCT
CGAGCGGCTGGCCAACGACGACGAGCCACTCGGACTGCCGGACGGCGCACTCGCCGGCTTCGTCCGGGCGGTGACCAACC
GGCGCGTCTTCACCGAGCCGACCAGCCCGCATGACGCGTGGCAGGCGGTCCACGCCCTGCTCGCGGCACCCGCCGCGGTG
CGGCTTCGACCCGGCGAGCGGCACTGGATGCTGTTCCGGCAACTCGTCGCCGATATCGATGCGAGCGGCAACGACATCGT
GGACGCGTATCTGGCCGCCTACGCCCTGGAGAACAACGCGACCTGGGTGAGCGCCGACCGCGGTTTCGCCCGCTTTCGCC
GGTTGCGCTGGCGTCATCCGCTGGATATGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9281.55 Da        Isoelectric Point: 4.7954

>AT186132 WP_219360902.1 NZ_CP067342:1921580-1921831 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAAILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT186132 NZ_CP089224:3421792-3422049 [Mycobacterium ostraviense]
ATGCGCACGACGATCCGGATCGACGACGAGCTCTACCGCGAGGTGAAGGCAAGGGCCGCGCGCTCCGGGCGCACTGTCGC
CGCGGTCCTCGAGGACGCGGTGCGGCGTGGTCTCAATCCGCCTGAACAGCCGGCGGCCGGCCGCTATCGGGTCCAGCCGA
CGGGCAGGGGCGGGCTTCGGCCCGGTGTGGACCTGTCTGCCAACGCTGCCGTCGCGGAGGCGATGGACGAGGGCGTGTCG
GTCGATGCTTTGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure

References