Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1191096..1191602 Replicon chromosome
Accession NZ_CP067336
Organism Actinomyces sp. HMT897

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag JJJ15_RS04830 Protein ID WP_200511619.1
Coordinates 1191096..1191350 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag JJJ15_RS04835 Protein ID WP_200511620.1
Coordinates 1191351..1191602 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JJJ15_RS04810 1186363..1187136 - 774 WP_200511615.1 histidine phosphatase family protein -
JJJ15_RS04815 1187241..1188224 + 984 WP_200511616.1 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase -
JJJ15_RS04820 1188335..1189171 - 837 WP_200511617.1 class I SAM-dependent methyltransferase -
JJJ15_RS04825 1189404..1190918 - 1515 WP_200511618.1 citrate synthase -
JJJ15_RS04830 1191096..1191350 - 255 WP_200511619.1 Txe/YoeB family addiction module toxin Toxin
JJJ15_RS04835 1191351..1191602 - 252 WP_200511620.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
JJJ15_RS04840 1191670..1192935 - 1266 WP_200511621.1 succinyldiaminopimelate transaminase -
JJJ15_RS04845 1193019..1193369 - 351 WP_106109710.1 ferredoxin family protein -
JJJ15_RS04850 1193717..1195771 - 2055 WP_200511622.1 VanW family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9940.36 Da        Isoelectric Point: 8.9016

>T186122 WP_200511619.1 NZ_CP067336:c1191350-1191096 [Actinomyces sp. HMT897]
VRLVWDPGAWEDYKHWQRADRRVLKRVNTLIDACLRDPHAGIGKPERLMYGAPGAWSRRITDEHRLVYLVDGDDLVILQA
RYHY

Download         Length: 255 bp

>T186122 NZ_CP089223:c1986924-1986346 [Mycobacterium avium subsp. avium]
ATGGAGCGACTCGACGTGGTGGTCGGGCCCAACGGCGCCGGCAAGTCGACGTTCATCGCGTTGACCCTGGCGCCGCTGCT
GCCGGGCAGCGTGGTGGTCAACGCCGACGAGATCGCGCGGCAGCGCTGGCCGCAGGATCCGGCGTCGCACGCCTACGACG
CCGCGAAGGTCGCCGCCGACACCCGGGCGAAGCTGATCGACCTGGGCCGGTCGTTCATCGCCGAGACCGTGTTCTCCCAC
CCGTCCAAGCTGGACCTGCTGCACGCCGCCCGCCGCGCCGGCTTCACCGTCGTGCTGCACGTGCTGCTCATCCCGGAAGA
CCTTGCCGTCGAACGGGTCCGGCACCGCGTGCGGGCCGGCGGCCATGACGTGCCGGAAACCAAGATCCGCGAGCGGCATC
GCCGGTTGTGGACTCCGGTCGCCGAGGCGATGACCCTGGCCGACCTGGCCACCGGCTACGACAACAGCCGGCTGCGCGGG
CCGCGTGTGGTGGCCCGGCTCAGCGGCGGGCTGACGGTCGGTGCCGTCGACTGGCCGGCGTGGGCACCCGAGACCTTGCG
GTCGCGTTGGCCGGTCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9404.55 Da        Isoelectric Point: 5.8374

>AT186122 WP_200511620.1 NZ_CP067336:c1191602-1191351 [Actinomyces sp. HMT897]
VSISVSQARRTLFPLIEQVTSDRVPVEIVSRKGSVVLMPADEYAAWQETAYLFRSPANARRLLDAYDRARAGRTEEHGLD
RED

Download         Length: 252 bp

>AT186122 NZ_CP089223:c1987344-1986955 [Mycobacterium avium subsp. avium]
ATGGCCGAGGCCGTCGATCGGGTCACCCGGGTCGCGTCCGATCTGATGGACAGCGCGGCGGCCGAGGGCGCCCGTCAGAG
CCGCTCGGCCAAGCAGCAGCTCGACCACTGGGCGCGGGTCGGGCGTGCGGTGTCCAGCCAGCACACCGCGTCCCGGCGGC
GGGTCGAAGCCGCGCTGGCCGGCCGGCTGTCCACCGCCGAACTCACCGTCGAAGAGGGCGTGGTGTTCAACGCCGAGATC
TCGGCGGCCATCGACGAAAGCCTGGCGCGCACCAACTACGGGGCGACGCTGGCCGGGCAGGGTGTCACCACGGTGGCCCT
CAACGACGATGGCGAGATCGTCGAGCACCGGCCCGACGGCACCGCGGTGGTGCTGGCCGGCCGGCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References