Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 640942..642530 | Replicon | chromosome |
Accession | NZ_CP067311 | ||
Organism | Escherichia coli strain 027_SK3 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | S1ELM3 |
Locus tag | JJB21_RS03300 | Protein ID | WP_001125439.1 |
Coordinates | 641208..642530 (+) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | JJB21_RS03295 | Protein ID | WP_001301023.1 |
Coordinates | 640942..641208 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
JJB21_RS03295 (640942) | 640942..641208 | + | 267 | WP_001301023.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
JJB21_RS03300 (641208) | 641208..642530 | + | 1323 | WP_001125439.1 | type II toxin-antitoxin system serine/threonine protein kinase toxin HipA | Toxin |
JJB21_RS03305 (642842) | 642842..643050 | + | 209 | Protein_657 | AraC family transcriptional regulator | - |
JJB21_RS03310 (643305) | 643305..644531 | + | 1227 | Protein_658 | fimbria/pilus outer membrane usher protein | - |
JJB21_RS03315 (644545) | 644545..645075 | + | 531 | WP_000876763.1 | fimbrial protein | - |
JJB21_RS03320 (645088) | 645088..645591 | + | 504 | WP_000825452.1 | fimbrial protein | - |
JJB21_RS03325 (645650) | 645650..646564 | + | 915 | WP_000520676.1 | fimbrial protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
inside | Genomic island | - | - | 640942..654647 | 13705 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49275.82 Da Isoelectric Point: 8.2482
>T186107 WP_001125439.1 NZ_CP067311:641208-642530 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK
Download Length: 1323 bp
>T186107 NZ_CP089218:3861377-3861799 [Mycobacterium kansasii]
GTGATCCTCGACTCGTCGGCCTTCGTCGCGCTCATCCAGGGCGAGGCTCCCTACACCGAACAGATCGCGGCAGCTCTCAC
TGGGGACCGAAGTCCGGTCATGTCAACGGCGAACGCAGCTGAATGCCTGATCGTGCTCACTAGCCGACACGGCTTCATCG
CCCGCACCGTCTTCGACCGCCTGCGATTCGAAATCAACCTCGGCTTCCAGCCGTTCAACTTCGAGCTCGCGATGGCCGCG
CATCTCGCATACCTGCGATATGGAAGGGGCCGACACCCTGCTGGCCTCAACTGCGGGGACACCATGGCCTACGCCACCGC
CAAACTCGCGCACGAACCGCTCATCGCGATCGGCAATGACTTCGCTCAAACAGACCTCGAATCCGACGGTGTCATCGGCT
ACTGGCCATCGCCCTGCGGCTAG
GTGATCCTCGACTCGTCGGCCTTCGTCGCGCTCATCCAGGGCGAGGCTCCCTACACCGAACAGATCGCGGCAGCTCTCAC
TGGGGACCGAAGTCCGGTCATGTCAACGGCGAACGCAGCTGAATGCCTGATCGTGCTCACTAGCCGACACGGCTTCATCG
CCCGCACCGTCTTCGACCGCCTGCGATTCGAAATCAACCTCGGCTTCCAGCCGTTCAACTTCGAGCTCGCGATGGCCGCG
CATCTCGCATACCTGCGATATGGAAGGGGCCGACACCCTGCTGGCCTCAACTGCGGGGACACCATGGCCTACGCCACCGC
CAAACTCGCGCACGAACCGCTCATCGCGATCGGCAATGACTTCGCTCAAACAGACCTCGAATCCGACGGTGTCATCGGCT
ACTGGCCATCGCCCTGCGGCTAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 10016.38 Da Isoelectric Point: 6.2267
>AT186107 WP_001301023.1 NZ_CP067311:640942-641208 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW
Download Length: 267 bp
>AT186107 NZ_CP089218:3861107-3861370 [Mycobacterium kansasii]
GTGGCATTCAACGTCAAGGATGAAGAGGTGATCCGCTTGGCCGATGAGCTCGCCGCACGTCTTCACCACCCGAGCCGCAT
CGACGCTATCCGGTATGCACTGCGCGCCCAGATCGAGATCACGCAGTCCCGCACTGCAAACCGTGCCGATGAACTCCTCG
ACGTCCTCAGAACCGAGATCTGGCCATTGCTGCACGATCGATCCCCGATCACCAAGTCCGAACGCGAACAAGCCCTCGGA
TACGACGCGGCGACGGGCGTGTGA
GTGGCATTCAACGTCAAGGATGAAGAGGTGATCCGCTTGGCCGATGAGCTCGCCGCACGTCTTCACCACCCGAGCCGCAT
CGACGCTATCCGGTATGCACTGCGCGCCCAGATCGAGATCACGCAGTCCCGCACTGCAAACCGTGCCGATGAACTCCTCG
ACGTCCTCAGAACCGAGATCTGGCCATTGCTGCACGATCGATCCCCGATCACCAAGTCCGAACGCGAACAAGCCCTCGGA
TACGACGCGGCGACGGGCGTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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