Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
| Location | 4217405..4218098 | Replicon | chromosome |
| Accession | NZ_CP067307 | ||
| Organism | Escherichia coli strain ABW_A19 | ||
Toxin (Protein)
| Gene name | mqsR | Uniprot ID | S1EZG2 |
| Locus tag | JJB22_RS19850 | Protein ID | WP_000415584.1 |
| Coordinates | 4217802..4218098 (-) | Length | 99 a.a. |
Antitoxin (Protein)
| Gene name | mqsA | Uniprot ID | S1EBV2 |
| Locus tag | JJB22_RS19845 | Protein ID | WP_000650107.1 |
| Coordinates | 4217405..4217800 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| JJB22_RS19835 (4213269) | 4213269..4215527 | - | 2259 | WP_001281841.1 | DNA topoisomerase IV subunit A | - |
| JJB22_RS19840 (4215665) | 4215665..4217272 | - | 1608 | WP_021577968.1 | ABC transporter substrate-binding protein | - |
| JJB22_RS19845 (4217405) | 4217405..4217800 | - | 396 | WP_000650107.1 | type II toxin-antitoxin system antitoxin MqsA | Antitoxin |
| JJB22_RS19850 (4217802) | 4217802..4218098 | - | 297 | WP_000415584.1 | type II toxin-antitoxin system toxin MqsR | Toxin |
| JJB22_RS19855 (4218303) | 4218303..4218785 | - | 483 | WP_021577969.1 | GyrI-like domain-containing protein | - |
| JJB22_RS19860 (4218838) | 4218838..4219230 | - | 393 | WP_021577970.1 | OB fold stress tolerance protein YgiW | - |
| JJB22_RS19865 (4219381) | 4219381..4220040 | + | 660 | WP_001221502.1 | quorum sensing response regulator transcription factor QseB | - |
| JJB22_RS19870 (4220037) | 4220037..4221386 | + | 1350 | WP_000673376.1 | quorum sensing histidine kinase QseC | - |
| JJB22_RS19875 (4221496) | 4221496..4222077 | + | 582 | WP_000065430.1 | NADPH:quinone oxidoreductase MdaB | - |
| JJB22_RS19880 (4222108) | 4222108..4222422 | + | 315 | WP_000958598.1 | putative quinol monooxygenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / qacE / sul1 / armA / msr(E) / mph(E) | rfaE | 4213269..4310234 | 96965 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11231.96 Da Isoelectric Point: 8.9070
>T186091 WP_000415584.1 NZ_CP067307:c4218098-4217802 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
Download Length: 297 bp
>T186091 NZ_CP089216:1864662-1865063 [Mycobacterium kansasii]
GTGATCGCGCTGCTGGACTCGAACGTGCTGATCGCACTGGTGGTCGCCGAACACGTCCATCACGACGTCGCCGCGGCATG
GCTGTCCGCGCGCGACAACGGCTTCGCGACGTGCCCAATCACGCAGGGAAGTCTGGTTCGATTCTTGATGCGGACGGGCC
AACCCGCCGCAGTTGCGCGGGAGGTGGTCGGAGCTGTCGAAACCGCAAAGCGCCACGAGTTCTGGCCCGACAGCGTCTCT
TTCGCCGATGTCGAGATCGGAGGGGTGGTCGGTCACCGACAGGTGACCGATGCCTACCTGGCGCAGCTGGCCCGAAGCCG
CAACGGGCAGTTGGCGACTCTCGATAGTGGACTGGCGCACTTGCACAGCGACGTCGCGGTCCTCATTCCCACGGCCGGCT
GA
GTGATCGCGCTGCTGGACTCGAACGTGCTGATCGCACTGGTGGTCGCCGAACACGTCCATCACGACGTCGCCGCGGCATG
GCTGTCCGCGCGCGACAACGGCTTCGCGACGTGCCCAATCACGCAGGGAAGTCTGGTTCGATTCTTGATGCGGACGGGCC
AACCCGCCGCAGTTGCGCGGGAGGTGGTCGGAGCTGTCGAAACCGCAAAGCGCCACGAGTTCTGGCCCGACAGCGTCTCT
TTCGCCGATGTCGAGATCGGAGGGGTGGTCGGTCACCGACAGGTGACCGATGCCTACCTGGCGCAGCTGGCCCGAAGCCG
CAACGGGCAGTTGGCGACTCTCGATAGTGGACTGGCGCACTTGCACAGCGACGTCGCGGTCCTCATTCCCACGGCCGGCT
GA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14703.10 Da Isoelectric Point: 9.2136
>AT186091 WP_000650107.1 NZ_CP067307:c4217800-4217405 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
Download Length: 396 bp
>AT186091 NZ_CP089216:1864438-1864665 [Mycobacterium kansasii]
GTGCGTACCACCATTGATCTTCCCGACGACCTCCACAAGCAAGCGCTGGCCATCGCCCGGGACACGCGCCGGACGTTGAG
TGAAACCGTCGCCGATCTCATGCGACGGGGCCTGGGGGCCGGCGGCGCCGCCGCGATCTCCACTGACCCGAGAACCGGGC
TGCCTCTGGTGAACGTCGGCAAAGTTGTCACCTCCGAGGACGTGCGCTCGTTGGAGGATGAGGAGTGA
GTGCGTACCACCATTGATCTTCCCGACGACCTCCACAAGCAAGCGCTGGCCATCGCCCGGGACACGCGCCGGACGTTGAG
TGAAACCGTCGCCGATCTCATGCGACGGGGCCTGGGGGCCGGCGGCGCCGCCGCGATCTCCACTGACCCGAGAACCGGGC
TGCCTCTGGTGAACGTCGGCAAAGTTGTCACCTCCGAGGACGTGCGCTCGTTGGAGGATGAGGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|